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陶涛教授博导

邮  箱:E-mail:taotao@xmu.edu.cn

职称/职务:教授

联系方式:+86-592-2186777,2182880

  • 个人简介
  • 科研领域
  • 代表性成果

1986年,武汉大学生物学专业,学士学位;
1989年,武汉大学生物学专业,硕士学位;
2001年,美国凯斯西储大学生物学专业,博士学位;
1989-1994年,武汉大学,助教/讲师/研究生院培养教育处副处长;
2001-2003年,加拿大McGill大学博士后 (Post-doctoral Fellow);
2004年至今,澳门大阳城集团澳门大阳城集团2138网站教授、博士生导师(PI);
2008-2012年,澳门大阳城集团研究生院副院长兼学位与学科建设办公室主任;
2012-2017年,澳门大阳城集团研究生院常务副院长;
2017年至今,澳门大阳城集团海外教育学院/国际学院院长。
B.S. 1986, Wuhan University, Biology;
M.S. 1989, Wuhan University, Biology;
Ph.D. 2001, Case Western Reserve University School of Medicine, Biology;
Post-doctoral Fellow, McGill University, Canada, 2001-2003;
Professor, Xiamen University School of Life Sciences, 2004 to Present;
Vice Dean, Graduate School, Xiamen University, 2008-2012;
Executive Dean, Xiamen University Graduate School, 2012-2017;
Dean, Overseas Education College/International College, Xiamen University, 2017 to Present.

我们实验室长期研究蛋白质在细胞核质间转运的分子机理和功能,特别关注负责蛋白质核质转运的受体(karyopherins)家族成员在细胞分化,组织发育及疾病发生中的转录调控和翻译后修饰的分子机理和生物学意义。

代表性论文(# co-first author, * Corresponding author):

1.Xiuyu Shi, Wenbo Lin, Xiang Gao, Wen Xie, Jeffrey A Golden*,Tao Tao*.(2020) Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein.Bioscience Reports, 40(7):BSR20194513, doi: 10.1042/BSR20194513. (*共同通讯作者)
2.Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa,Tao Tao*, Jeffrey A. Golden* (2020)PIK3R2/Pik3r2 activating mutations result in brain overgrowth and EEG changes.Annals of Neurology, accepted (*共同通讯作者)
3.Xujie Liu, Wenbo Lin, Xiuyu Shi, Rebecca G. Davies, Kylie M. Wagstaff,Tao Tao*, David A. Jans*. PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function.Biochemical Journal, Accepted (*共同通讯作者)2018
4.Huang N, Pei X, Lin W, Chiu JF,Tao T*, Li G*. DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells. Acta Biochim Biophys Sin(Shanghai). doi: 10.1093/abbs/gmy063.(*共同通讯作者)2018
5..Huang N, Lin W, Shi X,Tao T. STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival.Future Oncol. doi: 10.2217/fon-2018-0126. 2018
6.Sun S, Liu S, Zhang Z, Zeng W, Sun C,Tao T, Lin X, Feng XH. Phosphatase UBLCP1 controls proteasome assembly.Open Biol. 2017 7(5). pii: 170042. 2017
7.Xu P, Lin W, Liu F, Tartakoff A. & Tao T.Competitive regulation of IPO4 transcription by ELK1 and GABP. Gene,613, 30–38, 2017
8.Lin W, Xu P, Guo Y, Jia Q & Tao T. Nuclear import of Nkx2-2 is mediated by multiple pathways. Biochem Biophys Res Commun. 482,1511-1516, 2017
9.Sekhri P, Tao T, Kaplan F. & Zhang XD. Characterization of amino acid residues within the N-terminal region of Ubc9 that play a role in Ubc9 nuclear localization. Biochem Biophys Res Commun. 458,128-133, 2015
10..Lieu K, Shim EH, Wang JL, Lokareddy RK, Tao T, Cingolani G, Zambetti GP & Jans DA . The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain. Journal of Cell Biology, 205, 301-312, 2014
11.Yuan FQ, Ma YN, You P, Lin WB, Lu HJ, Yu YH, Wang XM, Jiang J, Yang PY, Ma QL,Tao T. A novel role of proteasomal β1 subunit in tumoriGenesis.Bioscience Reports,16:33 (4),2013
12.Ye WD, Lin WB, Tartakoff AM, Ma QL, Tao T. Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function.Molecular & Cellular Biochemistry,381(1-2):221-231,2013
13.You P, Peng Z, Wang YW and Tao T. Expression and subcellular distribution of importin 13 are regulated in brain development.In Vitro Cellular & Developmental Biology – Animal, 49(5):346-353. 2013
14.Yuan F, Lu J, You P, Yang Z, Yang P, Ma QL, Tao T. Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine.Proteomics 13:389-397, 2013
17.Xu K,Tao T, Jie J, Lu XD, Li XZ, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou YP, Liu ZG. Increased importin 13 activity is associated with the pathoGenesis of pterygium. Molecular Vision, 19:604-613, 2013
18.Ye WD, Lin WB, Tartakoff AM,Tao T. Karyopherins in nuclear transport of homeodomain proteins during developmentM.BBA Molecular Cell Research, 1813:1654-1662, 2011.
19.You P, Ma QL,Tao T. Gene diagnosis of oculopharyngeal muscular dystrophy in a Chinese family by a GeneScan method.Journal of Clinical Laboratory Analysis 24:1-4, 2010.
20.Tartakoff AM &Tao T. Comparative and evolutionary aspects of macromolecular translocation across membranes. International Journal of Biochemistry & Cell Biology, 42:214-229, 2010.
21.Huang S, Chang IS, Lin WB, Ye WD, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS,Tao T, Bast Jr RC, Chen X, Yu Y. ARHI (DIRAS 3), an imprinted tumor suppressor Gene, binds to importins, and blocks nuclear import process of cargo proteins.Bioscience Reports, 30: 159-168, 2010.
22.Wang H,Tao T, Tang J, Mao YH, Li W, Peng J, Tan G, Zhou YP, Zhong JX, Tseng SC, Kawakita T, Zhao YX, Liu ZG. Importin 13 serves as a potential marker for corneal epithelial progenitor cells. Stem Cells, 27: 2516-2526, 2009.
23.Lin WB, Ye WD, Cai LL, Meng XY, Ke GF, Huang CX, Peng Z, Yu YH, Golden JA, Tartakoff AM,Tao T. The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein.Journal of Biological Chemistry, 284: 20428-20439, 2009.
24.Quan Y, Ji ZL, Wang X, Tartakoff AM,Tao T. Evolutionary and transcriptional analysis of karyopherin β superfamily proteins. Molecular & Cellular Proteomics 7: 1254-1269, 2008.
25.Chen C, Huang CX, Chen SH, Liang J, Lin WB, Ke GF, Zhang HX, Wang B, Huang J, Han ZG, Ma LX, Huo KK, Yang XM, Yang PY, He FC,Tao T. Subunit-subunit interactions in the human 26s proteasome. Proteomics 8: 508-520 (cover paper, highlighted in Currents: Journal of Proteome Research, 7:1371), 2008.
26.Liang J, Ke GF, You WJ, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T.​ Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin. Molecular & Cellular Biochemistry, 307: 93-100, 2008.
27.Wang YP, Liang L, Han BC, Quan Y, Wang X,Tao T, Ji ZL. GEPS: the Gene Expression Pattern Scanner. Nucleic Acids Research, 34: W472-W497, 2006

荣誉、奖励及参加学术团体的情况:

1.基于蛋白质相互作用网络的p53功能调控机制研究(2013CB910803,2013-2017)“973”课题组长
2.揭示信号通路对中胚层干细胞体内自我更新和分化的生理调控机制(2012CB966602,2012-2016) “973”课题骨干
3.人类肝脏蛋白质相互作用研究 “863”重大项目子课题 2007-2010
4.NLS1介导的转录因子Arx在细胞核定位的分子机理研究(国家自然科学基金项目,2010-2012)
5.PSMB6在肝癌发生中的功能研究(国家自然科学基金项目,2011.01-2011.12)
6.Arx的细胞核质分布调控成肌细胞C2C12分化的分子机理研究(国家自然科学基金项目,2013-2016)