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靳全文教授博导

邮  箱:jinquanwen@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2187931

  • 个人简介
  • 科研领域
  • 代表性成果

1990年,东北师范大学生物学专业,学士学位;
1993年,东北师范大学遗传学专业,硕士学位;
1999年,奥地利维也那大学遗传学专业,博士学位;
1993-1995年,中国科学院遗传研究所植物染色体工程国家重点实验室,研究实习员;
1999-2002年,德国杜塞尔多夫大学,博士后(由洪堡奖学金资助);
2002-2006年,美国马萨诸塞大学医学院,博士后;
2006年,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 1990, Northeast Normal University, Biology;
M.S. 1993, Northeast Normal University, Genetics ;
Ph.D. 1999, University of Vienna, Genetics ;
Research Trainee, Institute of Genetics , Chinese Academy of Sciences, 1993-1995;
Postdoctoral Fellow, University of Duesseldorf, 1999-2002;
Postdoctoral Fellow, University of Massachusetts Medical School, 2002-2006;
Professor, School of Life Sciences, Xiamen University, 2006 to Present.


本课题组主要以裂殖酵母为模式生物,采用的实验方法和技术涉及遗传学、细胞生物学及分子生物学手段。
研究兴趣主要包括三个方面:

1. 纺锤体组装检验点在调控有丝分裂染色体精确分配中的功能研究。
我们最近的研究发现,核仁蛋白Dnt1可以结合到APC/C复合体 (anaphase-promoting complex /cyclosome)上,限制纺锤体检验点蛋白复合体(mitotic checkpoint complex, MCC)与APC/C的过多结合。这样可以确保在纺锤体检验点失活时,细胞可以更有效地起始有丝分裂后期,完成细胞分裂。 2. 细胞极性生长调控机制研究。
我们最近的研究发现,裂殖酵母中的泛素连接酶(E3 ubiquitin ligase) Dma1除了定位在纺锤体极SPB处外,还会定位在细胞的极性生长的末端。当DNA复制或损伤检验点激活时,Dma1会泛素化修饰极性生长因子Tip1,这一修饰会抑制Tip1招募Tea4等极性生长因子,使细胞的极性生长停滞,有利于细胞在应对DNA复制压力时的存活。 3. 异染色质形成的表观遗传调控机制研究。
真核细胞的染色质可以分为常染色质和异染色质。裂殖酵母中的异染色质形成需要RNAi依赖的和RNAi非依赖的机制。我们最近的研究发现,分子伴侣蛋白Hsp90与 RNAi依赖的异染色质形成机制中RITS复合物存在相互作用,参与促进RITS复合物以及其上游的ARC复合物的组装。Hsp90还直接影响基因转录沉默复合物SHREC的组装。而在端粒区,Hsp90则影响Shelterin复合物对于CLRC以及SHREC复合物的招募。这一机制在高等真核生物包括人类细胞中可能也是保守的。

Taking advantage of the extensive technical amenability of the fission Yeast Schizosaccharomyces pombe, our research group employs multi-disciplinary approaches, such as Genetics , cell biology and molecular biology, to dissect the detailed mechanisms how the positive and negative regulators control faithful chromosome segregation, cell polar growth and heterochromatin formation in eukaryotes.
Major interests of our ongoing research focus on: (1) the molecular mechanisms coordinating timely spindle assembly checkpoint (SAC) silencing with chromosome segregation fidelity at anaphase; (2) the molecular mechanisms coordinating Cell Cycle with cell polar growth; (3) the molecular mechanisms involved in the epigenetic regulation of heterochromatin formation.

代表性论文(# co-first author, * Corresponding author):

1.Da-Jie Deng, Qian-Cheng Xia, Guo-Song Jia, Fang Suo, Jia-Li Chen, Li Sun, Jin-Qing Wang, Shuang-Min Wang, Li-Lin Du, Yamei Wang*, Quan-Wen Jin*. (2021) Perturbation of kinetochore function using GFP-binding protein in fission Yeast . G3 Genes|Genomes| Genetics , jkab290.
2.Sun L, Liu XM, Li WZ, Yi YY, He X*, Wang Y*Jin QW*. (2020) The molecular chaperone Hsp90 regulates heterochromatin assembly through stabilizing multiple complexes in fission  Yeast . Journal of Cell Science . 133(13):jcs244863.
3.Bohnert KA, Rossi AM, Jin QW, Chen JS, Gould KL*. (2020) Phosphoregulation of the cytokinetic protein Fic1 contributes to fission  Yeast  growth polarity establishment. Journal of Cell Science . 133(18):jcs244392.
4.Zheng S, Dong F, Rasul F, Yao X, Jin QW, Zheng F, Fu C*. (2018) Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis. FEBS Journal. 285(13):2468-2480.
5.Qiu C, Yi YY, Lucena R, Wu MJ, Sun JH, Wang X, Jin QW*, Wang Y*. (2018) F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission  Yeast . Journal of Cell Science . 131(3):jcs202895.
6.Chen YH, Wang GY, Hao HC, Chao CJ, Wang Y*, Jin QW*. (2017) Facile manipulation of protein localization in fission Yeast  through binding of GFP-binding protein to GFP. Journal of Cell Science . 130(5):1003-1015.
7.Chen YH, Chen LH, An K, Wang Y*Jin QW*. (2015) A vector system for efficient and economical switching of a ura4+ module to three commonly used antibiotic marker cassettes in Schizosaccharomyces pombe. Yeast . 32(11):671-82.
8.Yu ZY, Zhang MT, Wang GY, Xu D, Keifenheim D, Franco A, Cansado J, Masuda H, Rhind N, Wang Y, Jin QW*. (2013) Fission Yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis by downregulating Wee1 kinase. Journal of Cell Science . 126(Pt 21):4995-5004.
9.Cipak L, Gupta S, Rajovic I, Jin QW, Anrather D, Ammerer G, McCollum D, Gregan J*. (2013) Crosstalk between casein kinase II and Ste20-related kinase Nak1. Cell Cycle . 12(6):884-888.
10.Wang Y, Li WZ, Johnson AE, Luo ZQ, Sun XL, Feoktistova A, McDonald WH, McLeod I, Yates JR 3rd, Gould KL, McCollum D*, Jin QW*. (2012) Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein Dma1 in fission Yeast . Molecular Biology of the Cell . 23:3348-3356.
11.Li WZ, Yu ZY, Ma PF, Wang Y and Jin QW*. (2010) A Novel Role of Dma1 in Regulating Forespore Membrane Assembly and Sporulation in Fission Yeast . Molecular Biology of the Cell . 21: 4349-4360.
12.Jin QW, Ray S, Choi SH and McCollum D*. (2007) The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission Yeast . Molecular Biology of the Cell . 18: 2924-2934.
13.Jin QW, Zhou M, Bimbo A, Balasubramanian MK and McCollum D*. (2006) A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors. Genetics . 172: 2101-2112.
14.Jin QW and McCollum D*. (2003) Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission Yeast Schizosaccharomyces pombe. Eukaryotic Cell . 2: 510-520.
15.Jin QW, Pidoux AL, Decker C, Allshire RC and Fleig U*. (2002) The mal2p protein is an essential component of the fission Yeast centromere. Molecular and Cellular Biology. 22: 7168-7183.
16.Davis L, Barbera M, McDonnell A, McIntyre K, Sternglanz R, Jin QW, Loidl J and Engebrecht J*. (2001) The Saccharomyces cerevisiaeMUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics . 157:1179-1189.
17.Jin QW, Fuchs J and Loidl J*. (2000) Rabl-like chromosome arrangement is a major determinant of Yeast interphase nuclear organization. Journal of Cell Science . 113:1903-1912.
18.Jin QW, Trelles-Sticken E, Scherthan H and Loidl J*. (1998) Yeast nuclei display prominent centromere clustering that is reduced in nondividing cells and in meiotic prophase. Journal of Cell Biology. . 141: 21-29.
19.Loidl J*, Jin QW and Jantsch M. (1998) Meiotic pairing and segregation of translocation quadrivalents in Yeast . Chromosoma . 107: 247-254.

荣誉、奖励及参加学术团体的情况: