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黄佳良教授博导

邮  箱:jhuang@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:实验室网址:
https://huanglab.xmu.edu.cn/
(请访问实验室网站,获取最新信息)

  • 个人简介
  • 科研领域
  • 代表性成果

2005年,福州大学生物工程专业,学士学位;
2008年,福州大学计算机软件与理论专业,硕士学位;
2012年,中国科学院遗传与发育生物学研究所生物信息学专业,博士学位;
2011-2013年,葛兰素史克上海医药研发有限公司,科学家;
2013-2018年,哈佛大学Dana-Farber癌症研究所/波士顿儿童医院,博士后;
2018年至今,澳门大阳城集团澳门大阳城集团2138网站,闽江学者特聘教授。
B.S. 2005, Fuzhou University, Bioengineering;
M.S. 2008, Fuzhou University, Computer Software and Theory;
Ph.D., 2012, Chinese Academy of Science, Bioinformatics;
Scientist, GlaxoSmithKline (China) R&D Co., Ltd., Shanghai, 2011-2013;
Postdoc, Dana-Farber Cancer Institute/Boston Children's Hospital, Harvard Medical School, 2013-2018;
Principal Investigator, School of Life Sciences, Xiamen University, 2018 to Present.


哺乳动物发育和癌症的表观遗传调控机制
本课题组利用生物信息学(干)和分子生物学(湿)等方法,研究哺乳动物发育和癌症的表观遗传调控机制。围绕某一特定生物学问题,基于现有/产生表观基因组学等图谱,利用生物信息学方法在系统层面提出具体的生物学假设,并采用CRISPR/cas9基因编辑等手段开展实验验证。具体研究方向包括(1)设计生物信息学算法,解决生物组学数据分析的定量问题;(2)整合已有表观基因组学数据,构建发育过程中的增强子动态调控网络,寻找关键调控因子;(3)与临床医生/生物学家合作,利用单细胞组学等技术,探索癌症发生和治疗的细胞异质性,寻找潜在药物靶标。
Our lab is interest in understanding the epigenetic regulation mechanisms of mammalian development and cancer using computational (dry) and experimental (wet) methods. Starting from a specific biological question, we generate or integrate publicly available genomic and epigenomic data to make a specific testable hypothesis at system level, following by the experimental validation using CRISPR/cas9 genome-editing assays. Our current research includes: (1) developing computational methods for quantification problems for various omics data; (2) elucidate the gene regulatory networks during development through integrating genomic, transcriptomic, and epigenomic data; (3) investigate the cellular heterogeneity during cancer progression and treatment response using single-cell analysis, which helps to identify potential drug targets..

代表性论文(# co-first author, * Corresponding author):

1.Y. Kai#, B. E. Li#, M. Zhu#, G. Y. Li, F. Chen, Y. Han, H. J. Cha, S. H. Orkin, W. Cai*, J. Huang*, G.-C. Yuan*. Mapping the evolving landscape of super-enhancers during cell differentiation. Genome Biology, 2021.
2.W. Cai#, J. Huang#, Q. Zhu, B. Li, D. Seruggia, P. Zhou, M. Nguyen, Y. Fujiwara, H. Xie, Z. Yang, D. Hong, P. Ren, J. Xu,.W. Pu, G.-C. Yuan* and S. H. Orkin*. Enhancer-dependence of cell-type-specific gene expression increases with developmental age. PNAS, 2020; 117: 35.
3.J. Huang#, K. Li#, W. Cai, X. Liu, Y. Zhang, S. H. Orkin, J. Xu*, G.-C. Yuan*. Dissecting super-enhancer hierarchy based on chromatin interactions. Nature Communications, 2018; 9:943.
4.J. Huang#, X. Liu#, D. Li#, Z. Shao#, H. Cao, Y. Zhang, E. Trompouki, T. V. Bowman, L. I. Zon, G.-C. Yuan, S. H. Orkin*, J. Xu*. Dynamic control of enhancer repertoires drives lineage and stage-specific transcription during hematopoiesis. Developmental Cell, 2016; 36, 9-23.
5.J. Huang, E. Marco, L. Pinello, G.-C. Yuan*. Predicting chromatin organization using histone marks. Genome Biology, 2015; 16, 162.
6.J. Huang, C. Niu, C. D.Green, L. Yang, H. Mei*, J.-D. J. Han*. Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network. PLoS Computational Biology, 2013; 9, e1002998.
7.J. Huang, Y. Liu, W. Zhang, H. Yu and J.-D. J. Han*. eResponseNet: a package prioritizing candidate disease genes through cellular pathways. Bioinformatics, 2011; 27, 2319-2320.
8.E.Marco#,W,Meuleman#,J.Huang#, K. Glass, L. Pinello, J. Wang, M. Kellis*, G.-C. Yuan*. Multi-scale chromatin state annotation using a hierarchical hidden Markov model. Nature Communications, 2017; 8, 15011.
9.S. Beyaz#, J. Kim#, L. Pinello#, Y. Hu, M. A. Kerenyi, P. P. Das, R. A. Barnitz, M. E. Xifaras, R. Dogum, J. Huang, W. N. Haining, O. Yilmaz, G.-C. Yuan, S. H. Orkin*, F. Winau*. The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells. Nature Immunology. 2017; 18, 184-195.
10.H. Xie, C. Peng, J. Huang, B. Li, W. Kim, E. Smith, Y. Fujiwara, J. Qi, G. Cheloni, P. P. Das, M. Nguyen, S. Li, J. E. Bradner, S. H. Orkin*. Chronic myelogenous leukemia initiating cells require Polycomb group protein EZH2. Cancer Discovery, 2016; 6, 1237-1247.
11.S. Luc, J. Huang, J. McEldoon, E. Somuncular, D. Li, C. Rhodes, S. Mamoor, S. Hou, J. Xu, S. H. Orkin*. Bcl11a-deficiency causes hematopoietic stem cell defects with an aging-like phenotype. Cell Reports, 2016; 16, 3181-3194.
12.J. Xu#, Z. Shao#, D. Li, H. Xie, W. Kim, J. Huang, J. E. Taylor, L. Pinello, K. Glass, J. D. Jaffe, G.-C. Yuan, S. H. Orkin*. Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions. Molecular Cell, 2015; 57, 304-316.

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