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崔勇教授博导

邮  箱:cuiyong@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2009年,武汉大学生物学,学士学位;
2011年,香港中文大学生物学,硕士学位;
2014年,香港中文大学生物学,博士学位;
2014-2020年,香港中文大学澳门大阳城集团2138网站,博士后;
2020年至今,澳门大阳城集团澳门大阳城集团2138网站,教授/博士生导师。
B.S. 2009, Wuhan University, Biology;
M.S. 2011, The Chinese University of Hong Kong, Biology;
Ph.D. 2014, The Chinese University of Hong Kong, Biology;
Postdoctoral Fellow, School of Life Sciences, The Chinese University of Hong Kong, 2014-2020;
Professor, School of Life Sciences, Xiamen University, 2020 to Present.


(1) 植物细胞和分子生物学
(2) 植物蛋白质运输和细胞器生成
(3) 植物生物反应器表达药用蛋白质
本课题组主要围绕植物内膜系统针对细胞器的生物发生及囊泡运输的分子机制开展研究。所有植物细胞都含有一套由多种细胞器组成的内膜系统,包括内质网、高尔基体、反式高尔基体网络、多囊泡体、自噬体和液泡等。这些细胞器在植物体各类信号有序调控下,准确而高效地产生,参与细胞内物质运输,对维持植物体生长发育和完成环境应答有着重要的生物学意义。一方面,课题组应用植物细胞生物学、遗传学和生物化学等方法并结合前沿的3D电子断层扫描技术,探索发掘植物体生理及应激状态下,调控细胞器的生成及囊泡运输过程中的关键分子,为改良农作物抗逆提供新思路。另一方面,课题组还积极开发和利用多种植物细胞器(如液泡和内质网等)作为生物反应器场所,表达和储存目标外源蛋白,并对其理化特性和生物活性开展分析。
(1) Plant Cell and Molecular Biology
(2) Protein Trafficking and Organelle Biogenesis in Plant Cells
(3) Plant Bioreactors for Pharmaceutical Proteins
Our research interests are organelle biogenesis and vesicle trafficking in plants. All plant cells contain an endomembrane system with functionally distinct membrane-bound organelles, including the endoplasmic reticulum (ER), Golgi apparatus, trans-Golgi network (TGN), multivesicular body (MVB), autophagosome and vacuole. These organelles are generated accurately and efficiently in a well-organized way so as to exert their essential functions in protein transport, plant growth and responses to the environment. On one hand, we use plant cell biological, genetic, biochemical approaches in combination with 3D electron tomography technique to investigate key genes that regulate organelle biogenesis and vesicle trafficking under developmental and stressful conditions in plants, in the hope of providing novel insights for stress resistance in agriculture. On the other hand, we are also actively developing and using plant organelles (such as the vacuole and the ER) as bioreactor compartments to express and store target recombinant proteins, with further analysis on their physicochemical properties and biological activities.

代表性论文(# co-first author, * Corresponding author):

1.Cui, Y.*, Gao, J., He, Y., and Jiang, L.* (2020). Plant extracellular vesicles.Protoplasma, 257, 3-12.

2.Cui, Y.*, Cao, W., He, Y., Zhao, Q., Wakazaki, M., Zhuang, X., Gao, J., Zeng, Y., Gao, C., Ding, Y., Wong, H.Y., Wong, W.S., Lam, H.K., Wang, P., Ueda, T., Rojas-Pierce, M., Toyooka, K., Kang, B.-H., and Jiang, L*. (2019). A whole-cell electron tomography model of vacuole biogenesis in Arabidopsis root cells.Nature Plants,5, 95-105.

3.Zhao, Q.1, Shen, J.1, Gao, C.1,Cui, Y.1, Wang, Y., Cui, J., Cheng, L., Cao, W., Zhu, Y., Huang, S., Zhou, Q., Leong, C.K., Leung, P., Chen, X., and Jiang, L.* (2019). RST1 is a FREE1 suppressor that negatively regulates vacuolar trafficking in Arabidopsis.Plant Cell,31, 2152-2168. (1Co-first Authors).

4.Cui, Y.*, Zhuang, X.*, Shen, J.*, Gao, C.*, and Jiang, L.* (2019). Organelle biogenesis and function in plants. SCIENTIA SINICA Vitae,49, 1679–1694.

5.Cui, Y.*, He, Y., Cao, W., Gao, J., and Jiang, L.* (2018). The multivesicular body and autophagosome pathways in plants.Frontiers in Plant Science, 9, 1837.

6.Cui, Y., Zhao, Q., Xie, H.T., Wong, W.S., Wang, X., Gao, C., Ding, Y., Tan, Y., Ueda, T., Zhang, Y., and Jiang, L.* (2017). MONENSIN SENSITIVITY1 (MON1)/CALCIUM CAFFEINE ZINC SENSITIVITY1 (CCZ1)-mediated Rab7 activation regulates tapetal programmed cell death and pollen development in Arabidopsis.Plant Physiology, 173, 206-218.

7.Zhuang, X.1, Chung, K.P.1,Cui, Y.1, Lin, W., Gao, C., Kang, B.H., Jiang, L.* (2017). ATG9 regulates autophagosome progression from the endoplasmic reticulum in Arabidopsis. Proc. Natl. Acad.Proc. Natl. Acad. Sci. USA 114, E426-E435. (1Co-first Authors).

8.Cui, Y., Shen, J., Gao, C., Zhuang, X., Wang, J., and Jiang, L.* (2016). Biogenesis of Plant Prevacuolar Multivesicular Bodies.Molecular Plant, 9, 774-786. (Cover Article).

9.Cui, Y.*, Gao, C., Zhao, Q., and Jiang, L.* (2016). Using fluorescent protein fusions to study protein subcellular localization and dynamics in Plant CellMethods in Molecular Biologyt, DOI: 10.1007/978-1-4939-6352-2_7.

10.Zhuang, X.1,Cui, Y.1, Gao, C., and Jiang, L.* (2015). Endocytic and autophagic pathways crosstalk in plants. Curr. Opin.Current Opinion in Plant Biology, 28, 39-47. (1Co-first Authors).

11.Cui, Y., Zhao, Q., Gao, C., Ding, Y., Zeng, Y., Ueda, T., Nakano, A., and Jiang, L.* (2014). Activation of the Rab7 GTPase by the MON1-CCZ1 Complex Is Essential for PVC-to-Vacuole Trafficking and Plant Growth in Arabidopsis.Plant Cell, 26, 2080-2097.

12.12.Cui, Y.*, Zhao, Q., Hu, S., and Jiang, L.* (2020). Vacuole biogenesis in plants: how many vacuoles, how many models?Trends in Plant Science, 25, 538-548.

荣誉、奖励及参加学术团体的情况:

国家教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖二等奖,2017年
全国微课教学大赛一等奖,2020年
国家高层次青年人才,2021年
澳门大阳城集团南强青年拔尖人才(A类),2021年