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徐庆妍副教授

邮  箱:xuqingyan@yahoo.com

职称/职务:副教授

联系方式:+86-592-2180328

  • 个人简介
  • 科研领域
  • 代表性成果

1992年,华西医科大学药物化学专业(今四川大学华西药学院),学士学位;
1995年,华西医科大学药物化学专业(今四川大学华西药学院),硕士学位;
2004年,澳门大阳城集团动物学专业,博士学位;
2006-2007年,法国斯特拉斯堡大学,访问学者;
1995年至今,澳门大阳城集团澳门大阳城集团2138网站,助教/讲师/副教授。
B.S. 1992, West China University of Medical Science, Medicinal Chemistry;
M.S. 1995, West China University of Medical Science, Medicinal Chemistry;
Ph.D. 2004, Xiamen University, Zoology;
Postdoctoral Fellow, Louis-Pasteur University, 2006-2007;
Lecturer/Assistant Professor/Associate Professor, School of Life Science, Xiamen University, 1995 to Present.

微生物药物学。从事与微生物活性代谢产物相关的研究。除抗菌、抗肿瘤活性外,目前主要从事抑制肿瘤坏死因子-α(TNF-α)活性的小分子化合物的研究,希望可以找到阻断TNF-α导致细胞坏死的信号通路的药物。
Microbial Pharmacology. The main research area lies in Microbial Pharmacology. More than antibacterial and antitumor activities, we focus on the research of compounds with anti-TNF-α activity. We hope to find inhibitors that block the necrosis signaling pathway of TNF-α from microorganisms.

代表性论文(# co-first author, * Corresponding author):

1. Liu J L., Hu Z Y., Huang Y J., Zheng Z H, Xu Q Y*. Aspochalasin U, a moderate TNF-α inhibitor fromAspergillus sp[J]. Journal of Antibiotics. 2012, 65 : 49-52.
2. Liu J L, Hu Z Y, Xu Q Y*. 3 '-(3-Hydroxyphenyl)-4-methylspiro benzo e 1,4 diazepine-3,2 '-oxirane -2,5(1H, 4H)-dione[J]. Acta Crystallographica Section E - Structure Reports Online, 2011, 67: O1670 - U1532.
3. Zimmermann M, Atmanene C, Xu Q Y, Fouillen L, Van Dorsselaer A, Bonnet D, Marsol C, Hibert M, Sanglier-Cianferani S, Pigault C, McNamara LK, Watterson DM, Haiech J*, Kilhoffer MC. Homodimerization of the Death-Associated Protein Kinase Catalytic Domain: Development of a New Small Molecule Fluorescent Reporter[J]. PLoS ONE, 2010, 5(11). E14120.
4. Zhan Y Y, Du X P, Chen H Z, Liu J J, Zhao B X, Huang D H, Li G D, Xu Q Y, Zhang M Q, Weimer B C, Chen D, Cheng Z, Zhang L R, Li Q X, Li S W, Zheng Z H, Song S Y, Huang Y J, Ye Z Y, Su W J, Lin S C, Shen Y M, Wu Q*. Cytosporone B is an agonist for nuclear orphan receptor Nur77 [J]. Nature Chemical Biology, 2008, 4(9):548-556.
5. Xu Z, Xu Q Y, Zheng Z H, Huang Y J*. Kribbella amoyensis sp. nov., isolated from the rhizosphere soil of a pharmaceutical plant,Typhonium giganteumEngl [J]. International Journal of Systematic and Evolutionary Microbiology, 2011. PMID: 21705443.

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