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郑世进教授博导

邮  箱:jamescheng@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:2188846
实验室主页

  • 个人简介
  • 科研领域
  • 代表性成果

2001年,台湾清华大学生命科学专业,学士学位;
2005年,台湾阳明大学微生物/免疫学专业,硕士学位;
2012年,荷兰奈梅亨大学生物医学专业,博士学位;
2013-2014年,荷兰奈梅亨大学医学中心,博士后;
2015-2016年,哈佛大学暨麻省理工学院布洛德研究所,资深博士后;
2016-2019年,台湾清华大学分子医学研究所,助理教授;
2019年,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 2001, National Tsing-Hua University, Bioscience;
M.S. 2005, National Yang-Ming University, Microbiology and Immunology;
Ph.D. 2012, Radboud University Nijmegen, the Netherlands, Biomedical Medicine;
Postdoctoral Fellow, University Medical Center Nijmegen, 2013-2014;
Senior Postdoctoral Fellow, Broad Institute of Harvard and MIT, 2015-2016;
Assistant Professor, Institute of Molecular Medicine, National Tsing-Hua University, 2016-2019
Professor, School of Life Sciences, Xiamen University, 2019 to Present.

本课题组长期围绕训练免疫(先天免疫记忆)开展研究。不同于后天免疫系统的记忆功能,先天免疫记忆不具有抗原专一性,乃是透过表观遗传与代谢重编程所介导,使得经过训练后的先天免疫系统针对后续的刺激产生非抗原特异性的记忆功能。目前已知疫苗、细菌及真菌感染等都有可能诱导训练免疫。目前课题组的研究方向包括在不同的生理病理状况下训练免疫如何产生、以及训练免疫在感染性疾病、炎症性肠病、肿瘤治疗等相关方面的应用。郑老师课题组欢迎所有对免疫学有兴趣的学生加入我们的研究团队!
Our lab has a long-term interest along the line of trained immunity. Trained immunity is a de facto immunological memory of innate immunity, characterized by the antigen-independent memory underlined by the epigenetic and metabolic reprogramming of the trained cells. Stimulants such as BCG vaccine and fungi etc., have been reported to induce trained immunity. Our current research directions include a dissection of the mechanisms of trained immunity induced by various (patho)physiological conditions and translational applications of trained immunity in infectious diseases, inflammatory bowel diseases, and cancer therapy. Students interested in immunology from various backgrounds are welcome to join Chenglab!

代表性论文(# co-first author, * Corresponding author):

1. Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG. mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 2014 26;345(6204):1250684.
2. Cheng SC#, Scicluna BP#, Arts RJ#, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG. Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 2016 Apr;17(4):406-13.
3. Arts RJ, Huang PK, Yang D, Joosten AB, Van der Meer JWM, Oppenheim JJ, Netea MG, Cheng SC* High-Mobility Group Nucleosome-Binding Protein 1 as Endogenous Ligand Induces Innate Immune Tolerance in a TLR4-Sirtuin-1 Dependent Manner in Human Blood Peripheral Mononuclear Cells. Frontiers in Immunology, 2018 9:256
4. Kumar V#, Cheng SC# Johnson MD, Smeekens SP, Wojtowicz A, Giamarellos-Bourboulis E, Karjalainen J, Franke L, Withoff S, Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H, Bauer H, Herrmann BG, Bochud PY, Marchetti O, Perfect JR, Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG. Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia. Nat Commun. 2014 8;5:4675

荣誉、奖励及参加学术团体的情况:

Veni laureate of Dutch Research Council,2015年
MOST outstanding talent award,2015年
MOST outstanding young investigator grant,2017年
NHRI Career Development Grant,2018年
NTHU Young Faculty Research Award,2018年
国家海外高层次青年人才,2019年
第七届厦门市台湾特聘专家,2020年
福建省免疫学会青年委员会分会,副主任委员,2020年