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张连茹教授

邮  箱:ru898@xmu.edu.cn

职称/职务:教授

联系方式:+86-592-8482781

  • 个人简介
  • 科研领域
  • 代表性成果

1987年,华东理工大学生物化学专业,学士学位;
2001年,武汉大学生物化学与分子生物学专业,硕士学位;
2004年,武汉大学生物化学与分子生物学专业,理学博士;
2004年至今,澳门大阳城集团澳门大阳城集团2138网站生物化学与生物技术系,副教授/教授。
B.S. 1987, East China University of Science and Technology, Biochemistry;
M.S. 2001, Wuhan University, Biochemistry and Molecular Biology;
Ph D. 2004, Wuhan University, Biochemistry and Molecular Biology;
Visiting Scholar, Skaggs School of Pharmacy & Pharmaceutical Sciences, UCSD, 2013-2014;
Associate Professor/Professor, School of Life Sciences, Xiamen University, 2004 to Present.

微生物等天然产物中基于分子靶点的潜在小分子药物的开发。
基于Hsp90靶点的小分子抑制剂类抗肿瘤等药物先导化合物的发现;Hsp90客户蛋白数据库的挖掘、客户蛋白的预测及靶点功能研究;小分子抑制剂对Hsp90介导的客户蛋白相关细胞信号通路及其代谢途径的网络调控机制及其与疾病的关联性分析。
Screening for drug leading compounds from Marine Microbial and other natural resources. Research interests mainly focus on the antitumor inhibitor of Hsp90; Based on the database of client proteins of Hsp90 to predict a potential client protein, in further to probe the mechanism of small inhibitor in regulating signal pathway and metabolism network.

代表性论文(# co-first author, * Corresponding author):

1. Y.F. Sun, S.Y. Xiao, J.J.Chen, M.M.Wang, Z.H.Zheng, S.Y. Song, and < L.R. Zhang*. Heat shock protein 90 mediates the apoptosis and autophage in nicotinic-mycoepoxydiene-treated HeLa cells. Acta Biochim Biophys Sin. 47(2015):451-458.
2. B.X.Ye, X.Deng,L.D. Shao, Y.Lu, R.Xiao,Y.J. Liu, Y.Jin, Y.Y.Xie, Y.Zhao, L.F.Luo, S.Ma, M.Gao, L.R.Zhang, J.He, W.N.Zhang, Y.Chen, C.F.Xia, M.Deng, T.X.Liu, Q.S.Zhao, S.J.Chen *,Z.Chen*.Vibsanin B Preferentially Targets HSP90β, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis. J Immunol, 194(2015):4489-4497.
3. P. Lin,Y.T. Yi,M.K. Lu,Miaomiao Wang,Yang Yang,Yue Lu,Siyang Song,Zhonghui Zheng,Xianming Deng,L.R.Zhang*. Heat shock protein 90 inhibitor mycoepoxydiene modulates kinase signaling in cervical cancer cells and inhibits in-vivo tumor growth, Anti-Cancer Drugs, 26(2015):25-34
4. W.Huang,MYe, L.R.Zhang, et al. FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation. Mol.Cancer,150(2014),13.
5. J.Geng, S.Y. Xiao, Z.H. Zheng, S.Y. Song, L.R. Zhang*. Gambogic acid protects from endotoxin shock by suppressing, Inflamm. Res. 62 (2013):165–172.
6. L.R. Zhang *, Y.T. Yi, Q.J Guo, et al. Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation, Cell. Signal. 24 (2012) 859–865.
7. Y.Y.Zhan,Y.Chen, Q.Zhang, J.J.Zhuang, M.Tian, H.Z. Chen, L.R.Zhang, ea al. Lin, Tianwei*,Wu, Qiao* The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat. Chem. Biol.8(2012):897-904.
8. B.B. Zhao, H.L. Shen,L.R. Zhang, et al. Gambogic acid activates AMP-activated protein kinase in mammalian cells,Biochem. Biophys. Res. Commun. 424 (2012) 100–104.
9. L.R. Zhang*, Y.T. Yi, J.J. Chen, et al. Gambogic acid inhibits Hsp90 and deregulates TNF-a/NF-κB in HeLa cells,Biochem. Biophys. Res. Commun. 403(2010)282-287.
10. J.J.Liu, H.N. Zeng,L.R. Zhang, et al. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro,Cancer Res. 70 (2010) 3628-3637.

荣誉、奖励及参加学术团体的情况: