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袁吉锋教授博导

邮  箱:jfyuan@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2007年,西安交通大学生物工程专业,学士学位;
2012年,新加坡南洋理工大学生物医学工程/软物质与功能材料专业,博士学位;
2012-2016年,新加坡国立大学,研究科学家;
2016-2017年,新加坡科技研究局,高级研究员;
2017-2018年,新加坡国立大学,研究员;
2018年至今,澳门大阳城集团澳门大阳城集团2138网站,闽江学者特聘教授。
B.E. 2007, Xi’an Jiaotong University, Bioengineering;
Ph.D. 2012, Nanyang Technological University, Biomedical Engineering;
Research Scientist, National University of Singapore, 2012-2016;
Senior Research Fellow, Agency for Science, Technology and Research, 2016-2017;
Research Fellow, National University of Singapore, 2017-2018;
Professor, Xiamen University, 2018 to Present.

关键词:合成生物学、代谢工程、生物传感器、肠道益生菌、基因组编辑、天然产物、生物制造。
研究领域
课题组致力于通过合成生物学技术、代谢工程手段设计和构建高效细胞工厂用于生产各类高附加值产品;植物天然产物途径的异源解析;生物传感器用于疾病、病原体的高灵敏度诊断与检测;肠道益生菌的精准治疗策略。
具体研究内容包括:
a) 代谢工程优化细胞工厂;
b) 级联生物催化途径的设计与开发;
c) 生物传感器的设计与开发;
d) 植物天然产物生源途径的解析与微生物异源合成;
e) 益生菌的精准设计与疾病治疗。
KEYWORDS: Synthetic Biology, Metabolic Engineering, Biosensor, Probiotics, Genome Editing, Natural Products, Bio-manufacturing.
RESEARCH AREA:
By employing synthetic biology and metabolic engineering principles, our group focuses on devising efficient microbial cell factory for chemical productions, elucidating the biosynthetic pathways of natural products, developing biosensors for pathogen detection and probiotics-based disease treatment. More specifically, a) metabolic engineering toward more efficient cell factories; b) cascaded enzyme catalysis; c) biosensor design; d) pathway elucidation and microbial synthesis of plant natural products; e) probiotics-based disease treatment.

代表性论文(# co-first author, * Corresponding author):

1. Yanlin Li, Jing Wang, Linyong Li, Wenhui Song, Ming Li, Xin Hua, Yu Wang, Jifeng Yuan*, Zheyong Xue*. Natural products of pentacyclic triterpenoids: from the discovery to heterologous biosynthesis. Natural Product Reports, 2022 under review
2. Qiwen Mo, Wei Song, Zheyong Xue*, Jifeng Yuan*. Multi-level engineering of Saccharomyces cerevisiae for synthesis and accumulation of retinal. Green Chemistry, 2022, under revision
3. Jifeng Yuan*#, Jie Cheng#, Cong Fan, Peiling Wu, Yang Zhang, Mingfeng Cao, Tuo Shi*. Development of shuttle vectors for rapid prototyping of engineered Synechococcus sp. PCC 7002. Applied Microbiology and Biotechnology, 2022, under revision
4. Taiwei Yang, Peiling Wu, Yang Zhang, Mingfeng Cao, Jifeng Yuan*. High-titre production of aromatic amines in metabolically engineered Escherichia coli. Journal of Applied Microbiology, 2022, doi:10.1111/jam.15745
5. Cong Fan#, Danli Zhang#, Qiwen Mo, Jifeng Yuan*. Engineering Saccharomyces cerevisiae-based biosensors for copper detection. Microbial Biotechnology, 2022, doi:10.1111/1751-7915.14105
6. Yang Zhang*, Jie Cheng, Yuting He, Jifeng Yuan*. Photo-fermentative hydrogen production performance of a newly isolated Rubrivivax gelatinosus YP03 strain with acid tolerance. International Journal of Hydrogen Energy, 2022, 47(48), 20784-20792
7. Wei Song#, Chunchun Zhang#, Jiali Wu, Jianzhao Qi, Xin Hua, Liping Kang*, Qiang Yuan*, Jifeng Yuan*, Zheyong Xue*. Characterization of three Paris polyphylla glycosyltransferases from different UGT families for steroid functionalization. ACS Synthetic Biology, 2022, 11(4), 1669-1680
8. Yuling Zhu, Jifeng Yuan*. A Four-Step Enzymatic Cascade for Efficient Production of L-Phenylglycine from Biobased L-Phenylalanine. ChemBioChem, 2022, 23(8), e202100661
9. Yumeng Lai#, Haofeng Chen#, Lingrui Liu#, Bixia Fu, Peiling Wu, Wanrong Li, Junyan Hu, Jifeng Yuan*. Engineering a Synthetic Pathway for Tyrosol Synthesis in Escherichia coli. ACS Synthetic Biology, 2022, 11(1), 441–447
10. Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan*. Microbial synthesis of 4-hydroxybenzoate from renewable feedstocks. Food Chemistry: Molecular Sciences, 2021, 3, 100059
11. Bixia Fu, Gezhi Xiao, Yang Zhang, Jifeng Yuan*. One-Pot Bioconversion of Lignin-Derived Substrates into Gallic Acid. Journal of Agricultural and Food Chemistry, 2021, 69(38), 11336–11341
12. Bixia Fu#, Gezhi Xiao#, Yuling Zhu, Yueyang Chen, Yumeng Lai, Jifeng Yuan*. Renewable Vanillylamine Synthesis from Lignin-Derived Substrates. ACS Agricultural Science and Technology, 2021,1(5), 566–571
13. Yang Zhang, Xiaohui Song, Yumeng Lai, Qiwen Mo, Jifeng Yuan*. High-yielding terpene-based biofuel production in Rhodobacter capsulatus. ACS Synthetic Biology, 2021, 10(6), 1545–1552
14. Yufen Chen#, Bixia Fu#, Gezhi Xiao, Liang-Yu Ko, Tzu-Yu Kao, Cong Fan, Jifeng Yuan*. Bioconversion of Lignin-Derived Feedstocks to Muconic Acid by Whole-Cell Biocatalysis. ACS Food Science and Technology, 2021, 1(3), 382–387
15. Yang Zhang, Jifeng Yuan*. CRISPR/Cas12a-mediated genome engineering in the photosynthetic bacterium Rhodobacter capsulatus. Microbial Biotechnology, 2021, 14(6), 2700–2710
16. Qiwen Mo#, Huiyu Chen#, Cong Fan#, Danli Zhang, Lingrui Liu, Bixia Fu, Jifeng Yuan*. Utilization of a styrene-derived pathway for 2-phenylethanol production in budding yeast. Applied Microbiology and Biotechnology, 2021, 105(6), 2333-2340
17. Jifeng Yuan*, Qiwen Mo, Cong Fan. New Set of Yeast Vectors for Shuttle Expression in Escherichia coli. ACS Omega, 2021, 6(10), 7175–7180
18. Peiling Wu#, Yufen Chen#, Mingyu Liu, Gezhi Xiao, Jifeng Yuan*. Engineering an Optogenetic CRISPRi Platform for Improved Chemical Production. ACS Synthetic Biology, 2021, 10(1), 125-131
19. Yuling Zhu#, Taiwei Yang#, Yueyang Chen, Cong Fan, Jifeng Yuan*. One-Pot Synthesis of Aromatic Amines via Whole-Cell Biocatalysis. Chemistryselect, 2020, 5, 14292-14295
20. Yufen Chen#, Peiling Wu#, Liang-Yu Ko, Tzu-Yu Kao, Lijun Liu, Yang Zhang, Jifeng Yuan*. High-yielding protocatechuic acid synthesis from L-tyrosine in Escherichia coli. ACS Sustainable Chemistry and Engineering, 2020, 8(39), 14949-14954
21. Baiyun Zeng#, Yumeng Lai#, Lijun Liu, Jie Cheng, Yang Zhang, Jifeng Yuan*. High-yielding hydroxytyrosol synthesis from biobased L-tyrosine via cascade biotransformation. Journal of Agricultural and Food Chemistry, 2020, 68(29), 7691–7696
22. Zuoxi Mao#, Lijun Liu#, Yang Zhang#, Jifeng Yuan*. Efficient Synthesis of Phenylacetate and 2-Phenylethanol via One-Pot Cascade Biocatalysis. ChemBioChem, 2020, 21(18), 2676-2679
23. Lijun Liu, Yuling Zhu, Yufen Chen, Huiyu Chen, Cong Fan, Qiwen Mo, Jifeng Yuan*. One‐Pot Cascade Biotransformation for Efficient Synthesis of Benzyl Alcohol and Its Analogs. Chemistry - An Asian Journal, 2020, 15(7),1018-1021
24. Yang Zhang*, Jifeng Yuan*, Liejing Guo. Enhanced bio-hydrogen production from cornstalk hydrolysate pretreated by alkaline-enzymolysis with orthogonal design method. International Journal of Hydrogen Energy, 2020, 45(6),3750-3759
25. Jifeng Yuan, Benedict Ryan Lukito, Zhi Li*. De novo synthesis of (S)- and (R)-phenylethanediol in yeast via artificial enzyme cascades. ACS Synthetic Biology, 2019, 8(8), 1801-1808
26. Jifeng Yuan*, Xue Chen, Pranjul Mishra, Chi-Bun Ching. Metabolically engineered budding yeast for enhanced production of isoamyl alcohol. Applied Microbiology and Biotechnology. 2017, 101(1):465-475
27. Jifeng Yuan*, Chi-Bun Ching. Mitochondrial acetyl-CoA utilization pathway for terpenoid productions. Metabolic Engineering. 2016, 38:303-308
28. Jifeng Yuan*, Pranjul Mishra, Chi-Bun Ching. Metabolically engineered Saccharomyces cerevisiae for branched-chain ester productions. Journal of Biotechnology. 2017; 239:90-97
29. Wen Xu#, Jifeng Yuan*#, Shuiyun Yang, Chi-Bun Ching, Jiankang Liu. Programming saposin-mediated compensatory metabolic sinks for enhancing ubiquinone productions. ACS Synthetic Biology. 2016, 5(12):1404-1411
30. Jifeng Yuan*, Pranjul Mishra, Chi-Bun Ching. Engineering the leucine biosynthetic pathway for isoamyl alcohol production in budding yeast. Journal of Industrial Microbiology and Biotechnology. 2016, 44(1):107-117
31. Jifeng Yuan*, Chi-Bun Ching. Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae. Microbial Cell Factories. 2015, 14, 38
32. Jifeng Yuan*, Chi-Bun Ching. Combinatorial assembly of large biochemical pathways into yeast chromosomes for improved production of value-added compounds. ACS Synthetic Biology. 2015, 4(1):23-31
33. Jifeng Yuan*, Chi-Bun Ching. Combinatorial engineering of mevalonate pathway for improved amorpha-4,11-diene production in budding yeast. Biotechnology and Bioengineering. 2014, 111(3):608-617
34. Jifeng Yuan*, Hongcai Gao, Jianjun Sui, Hongwei Duan, Wei Ning Chen, Chi-Bun Ching. Cytotoxicity evaluation of oxidized single-walled carbon nanotubes and graphene oxide on human hepatoma HepG2 cells: An iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicological Sciences. 2012, 126(1):149-156
35. Jifeng Yuan*, Hongcai Gao, Chi-Bun Ching. Comparative protein profile of human HepG2 cells treated with graphene and single-walled carbon nanotubes: An iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicology Letters. 2011, 15; 207(3); 213-221
36. Jifeng Yuan*, Hongcai Gao, Jianjun Sui, Wei Ning Chen, Chi-Bun Ching. Cytotoxicity of single-walled carbon nanotubes on human hepatoma HepG2 cells: an iTRAQ-coupled 2D LC-MS/MS proteome analysis. Toxicology In Vitro. 2011, 25(8): 1820-1827

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