澳门大阳城集团2138网站|主頁-欢迎您!

ENGLISH

检测到您当前使用浏览器版本过于老旧,会导致无法正常浏览网站;请您使用电脑里的其他浏览器如:360、QQ、搜狗浏览器的极速模式浏览,或者使用谷歌、火狐等浏览器。

下载Firefox
肖能明教授博导

邮  箱:nengming@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2880352

  • 个人简介
  • 科研领域
  • 代表性成果

2000年,北京师范大学生物化学专业,学士学位;
2006年,北京大学生物化学与分子生物学专业,博士学位;
2006-2009年,美国斯克利普斯研究所,博士后;
2009-2010年,美国克利夫兰医学中心,博士后;
2010-2014年,美国拉霍亚过敏与免疫研究所,博士后;
2014年至今,澳门大阳城集团澳门大阳城集团2138网站教授。
B.S. 2000, Beijing Normal University, Biochemistry;
Ph.D., January 2006, Peking University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, The Scripps Research Institute, 2006-2009;
Postdoctoral Fellow, Cleveland Clinic, Cleveland, 2009-2010;
Postdoctoral Fellow, La Jolla Institute for Allergy and Immunology, 2010-2014;
Professor, School of Life Sciences, Xiamen University, 2014 to Present.

主要研究T细胞活化和分化(滤泡辅助性T细胞、细胞毒性T细胞和调节性T细胞)的分子机制,及其在抗病毒、抗肿瘤T细胞免疫应答以及自身免疫疾病中的作用。
To investigate molecular mechanism underlying activation and differentiation of T cells (including Follicular helper T cells, Cytotoxic T cells, Regulatory T cells), and their roles in antiviral and antitumor immune responses as well as autoimmune diseases.

代表性论文(# co-first author, * Corresponding author):

1. Chen Q, Zhuang S, Hong Y, Yang L, Guo P, Mo P, Peng K* , Li W*, Xiao N*, Yu C*. Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene. 2022;41(10):1421-1433.
2. Zhai X#, Liu K#, Fang H#, Zhang Q, Gao X, Liu F, Zhou S, Wang X, Niu Y, Hong Y, Lin SH, Liu WH, Xiao C, Li Q*, Xiao N*. Mitochondrial C1qbp promotes differentiation of effector CD8(+) T cells via metabolic-epigenetic reprogramming. Sci Adv. 2021;7(49):eabk0490.
3. Yang L#, Chen W#*,, Li L, Xiao Y, Fan S, Zhang Q, Xia T, Li M, Hong Y, Zhao T, Li Q, Liu WH*, Xiao N*. Ddb1 Is Essential for the Expansion of CD4(+) Helper T Cells by Regulating Cell Cycle Progression and Cell Death. Front Immunol. 2021;12:722273.
4. Xiao N, Eto D, Elly C, Peng G, Crotty S*, Liu YC*. The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells. Nat Immunol. 2014;15(7):657-666.
5. Siggs OM#, Xiao N#, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B*. iRhom2 is required for the secretion of mouse TNFalpha. Blood. 2012;119(24):5769-5771.
6. Xu L#, Xiao N#, Liu F, Ren H, Gu J*. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci USA. 2009;106(5):1530-1535.
7. Xiao N, Eidenschenk C, Krebs P, Brandl K, Blasius AL, Xia Y, Khovananth K, Smart NG, Beutler B*. The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease. J Immunol. 2009;183(12):7975-7983.

荣誉、奖励及参加学术团体的情况: