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陈兰芬教授博导

邮  箱:chenlanfen@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2880305

  • 个人简介
  • 科研领域
  • 代表性成果

1997年,澳门大阳城集团生物学专业,学士学位;
2000年,澳门大阳城集团生物学专业,硕士学位;
2006年,美国耶希瓦大学病理学专业,博士学位;
2007-2012年,哈佛大学医学院,博士后;
2012-2013年,澳门大阳城集团澳门大阳城集团2138网站,副教授;
2013年至今,澳门大阳城集团澳门大阳城集团2138网站,教授
B.S. 1997, Xiamen University, Biology;
M.S. 2000, Xiamen University, Biology;
Ph.D. 2006, Pathology, Yeshiva University;
Postdoctoral Fellow, Harvard Medical School, 2007-2012;
Associate Professor, School of Life Sciences, Xiamen University, 2012-2013;
Professor, School of Life Sciences, Xiamen University, 2011 to Present.

Hippo信号通路的Mst1激酶是T细胞活化,增殖和成熟的重要调节分子。本课题组主要研究Hippo信号通路在免疫系统功能调控、细胞分化、衰老及稳态维持等细胞生命活动中的功能及其调控机制。实验室目前的研究方向有:
(1)T细胞免疫耐受与自身免疫疾病发生;
(2)天然免疫调节与宿主抗感染的功能;
(3)肿瘤免疫调节与微环境重塑及干预。
The Hippo kinase Mst1, a homolog of the Drosphila tumor suppressor hippo, is a key determinant of peripheral T cell activation, proliferation and maturation. The combined deletion of Mst1 and Mst2 from the hematopoietic compartment results in the absence of all peripheral lymphocytes and a profound immunodeficiency syndrome. Our research group proposes to characterize the regulation and physiologic functions of the Hippo pathway in the immune system.

代表性论文(# co-first author, * Corresponding author):

1. Qingxu Liu#; Jiaxin Li#; Weiji Zhang#; Chen Xiao#; Shihao Zhang#; Cheng Nian; Junhong Li; Dongxue Su; Lihong Chen; Qian Zhao; Hui Shao; Hao Zhao; Qinghua Chen; Yuxi Li; Jing Geng; Lixin Hong; Shuhai Lin; Qiao Wu; Xianming Deng; Rongqin Ke; Jin Ding; Randy L. Johnson; Xiaolong Liu; Lanfen Chen*; Dawang Zhou*. Glycogen accumulation and phase separation drives liver tumor initiation. Cell. 2021 Oct 28; 184(22):5559-5576.e19.
2. Jing Geng#; Yiran Shi#; Jinjia Zhang#; Bingying Yang; Ping Wang; Weihong Yuan; Hao Zhao; Junhong Li; Funiu Qin; Lixin Hong; Changchuan Xie; Xianming Deng; Yujie Sun; Congying Wu; Lanfen Chen*; Dawang Zhou*. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection. Nature Communications. 2021 Jun 10, 12(1):3519.
3. Ping Wang#; Jing Geng#; Jiahui Gao; Hao Zhao; Junhong Li; Yiran Shi; Bingying Yang; Chen Xiao; Yueyue Linghu; Xiufeng Sun; Xin Chen; Lixin Hong; Funiu Qin; Xun Li; Jau-Song Yu; Han You; Zengqiang Yuan; Dawang Zhou; Randy L. Johnson;Lanfen Chen*. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nature Communications. 2019 Feb 14; 10(1):755.
4. Shihao Zhang#; Qinghua Chen#; Qingxu Liu#;Yuxi Li; Xiufeng Sun; Lixin Hong; Suyuan Ji; Chenyan Liu; Jing Geng; Weiji Zhang; Zhonglei Lu; Zhen-Yu Yin; Yuanyuan Zeng; Kwang-Huei Lin; Qiao Wu; Qiyuan Li; Keiko Nakayama; Keiich I Nakayama; Xianming Deng; Randy L Johnson; Liang Zhu; Daming Gao; Lanfen Chen*; Dawang Zhou*. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell. 2017 May 8; 31(5):669-684.e7.
5. Jing Geng#; Shujuan Yu#; Hao Zhao#; Xiufeng Sun#; Xun Li; Ping Wang; Xiaolin Xiong; Lixin Hong; Changchuan Xie; Jiahui Gao; Yiran Shi; Jiaqi Peng; Randy L Johnson; Nengming Xiao; Linrong Lu; Jiahuai Han; Dawang Zhou*; Lanfen Chen*. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nature Immunology. 2017 Jul; 18(7):800-812.
6. Jing Geng#; Xiufeng Sun#; Ping Wang; Shihao Zhang; Xiaozhen Wang;Hongtan Wu; Lixin Hong; Changchuan Xie;Xun Li; Hao Zhao; Qingxu Liu; Mingting Jiang; Qinghua Chen; Jinjia Zhang;, Yang Li; Siyang Song; Hong-Rui Wang; Rongbin Zhou; Randy L Johnson; Kun-Yi Chien; Sheng-Cai Lin; Jiahuai Han; Joseph Avruch; Lanfen Chen*; Dawang Zhou*. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunology. 2015 Nov; 16(11):1142-52.
7. Hongtan Wu#; Luyao Wei#; Fuqin Fan#; Suyuan Ji#; Shihao Zhang; Jing Geng; Lixin Hong; Xin Fan; Qinghua Chen; Jing Tian; Mingting Jiang; Xiufeng Sun; Changnan Jin; Zhen-Yu Yin; Qingxu Liu; Jinjia Zhang; Funiu Qin; Kwang-Huei Lin; Jau-Song Yu; Xianming Deng; Hong-Rui Wang; Bin Zhao; Randy L Johnson; Lanfen Chen*; Dawang Zhou*. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nature Communications. 2015 Feb 19; 6:6239.
8. Hongtan Wu#; Yubo Xiao#; Shihao Zhang#; Suyuan Ji; Luyao Wei; Fuqin Fan; Jing Geng; Jing Tian; Xiufeng Sun; Funiu Qin; Changnan Jin; Jianjun Lin; Zhen-Yu Yin; Ting Zhang; Lianzhong Luo; Yang Li; Siyang Song; Sheng-Cai Lin,; Xianming Deng; Fernando Camargo; Joseph Avruch; Lanfen Chen* and Dawang Zhou*. The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense. Cell Reports. 2013 May 30; 3:1663-1677.

荣誉、奖励及参加学术团体的情况:

第十七届中国青年女科学家奖,2021年
福建省自然科学一等奖,2020年
国家杰出青年科学基金项目,2019年
闽江学者奖励计划(特聘教授),2015年
国家优秀青年科学基金项目,2014年
国家高层次青年人才,2014年

Immunology Letters,编委
《中国免疫学杂志》,编委
中国免疫学会,监事会副监事
中国病理生理学会免疫专业委员会,副主任委员
中国免疫学会女科学家工作委员会,委员
福建省免疫学会,副理事长
福建省免疫学会肿瘤免疫与生物治疗专业委员会,副主任委员
厦门生物化学与分子生物学学会,常务理事