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刘敏助理教授

邮  箱:minliu@xmu.edu.cn

职称/职务:特任副研究员

联系方式:+86-592-2184533

  • 个人简介
  • 科研领域
  • 代表性成果

2002年,澳门大阳城集团生物学专业,学士学位;
2008年,澳门大阳城集团细胞生物学专业,博士学位;
2009-2013年,美国加州大学伯克利分校分子与细胞生物学系,博士后;
2014年至今,澳门大阳城集团澳门大阳城集团2138网站,助理教授;
2020年至今,澳门大阳城集团澳门大阳城集团2138网站,特任副研究员。
B.S. 2002, Xiamen University, Biology;
Ph.D. 2008, Xiamen University, Cell Biology;
Postdoc, University of California, Berkeley, 2009-2013;
Assistant Professor, School of Life Sciences, Xiamen University, 2014 to Present.

基因转录相关事件及其生理病理的功能。基因转录相关事件主要包括基因转录的过程及调控、RNA剪辑、表观遗传与基因转录调控;我们主要关注转录正常情况下细胞生长、分化以及转录异常情况下肥胖、炎症和癌症等人类切身相关的疾病。目前课题组主要采用传统生物学(包括生物化学和细胞生物学)和当代生物学(即生物信息学)等技术手段进行相关研究。

代表性论文(# co-first author, * Corresponding author):

1. Kai Zhou(#), Songkuan Zhuang(#), Fulong Liu(#), Yanheng Chen(#), You Li, Shihui Wang, Yuxuan Li, Huixin Wen, Xiaohua Lin, Jie Wang, Yue Huang, Cailing He, Nan Xu, Zongshu Li, Lang Xu, Zixuan Zhang, Lin-Feng Chen(*), Ruichuan Chen(*), Min Liu(*). Disrupting the Cdk9/Cyclin T1 Heterodimer of 7SK snRNP for the Brd4 and AFF1/4 Guided Reconstitution of Active P-TEFb. Nucleic Acids Res. , 2022, 50(2):750-762. DOI: 10.1093/nar/gkab1228 (SCI影响因子:16.971)
2. Shengkai Huang(#), Yan Li(#), Xinghua Yuan, Mei Zhao, Jia Wang, You Li, Yuan Li, Hong Lin, Qiao Zhang, Wenjie Wang, Dongdong Li, Xin Dong, Lan-Fen Li, Min Liu(*), Weiyan Huang(*) and Changzhi Huang(*). The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21. Cell Death Differ. , 2019, 26(3):516-530. (SCI影响因子:8)
3. Duchu Chen(#), Youde Liang(#), Liang Peng(#), Yize Wang, Chunzhi Ai, XinXing Zhu, Yawei Yan, Yasmeen Saeed, Bin Yu, Jingying Huang, Yuxin Gao, Jiaqi Liu, Yizhou Jiang, Min Liu(*) and Demeng Chen(*). CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma, Cancer Cell Int. , 2017, 17: 103. (SCI影响因子:2.74)
4. Xiaodong Lu(#), Xinxing Zhu(#), You Li(#), Min Liu(#), Bin Yu, Yu Wang, Muhua Rao, Haiyang Yang, Kai Zhou, Yao Wang, Yanheng Chen, Meihua Chen, Songkuan Zhuang, Lin-Feng Chen(*), Runzhong Liu(*) and Ruichuan Chen(*). Multiple P-TEFbs cooperatively regulate the release of promoter-proximally paused RNA polymerase II. Nucleic Acids Res. , 44(14), 6853-6867, 2016. (影响因子:10.162),被国际著名专家在线评论推荐网站Faculty 1000所推荐
5. Duchu Chen(#), Huiping Wang, Jude Juventus Aweya, Yanheng Chen, Meihua Chen, Xiaomeng Wu, Xiaonan Chen, Jing Lu, Ruichuan Chen, and Min Liu(*). HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20/TNFAIP3 in NF-κB Signaling. BioMed Res. Int. , 2016; 2016: 5173205. (影响因子2.476)
6. Min Liu(#)(*), You Li, Ruichuan Chen(*). CaMKII: Do Not Work Too Hard in the Failing Heart (Invited Commentary). Journal of Pathology. 2015 Apr; 235(5):669-71. (影响因子: 7.381)
7. Min Liu(#), Joanne Hsu, Caleb Chan, Zichong Li, Qiang Zhou(*). The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. Mol. Cell, 46(3), 325-334, 2012. (影响因子: 15.28)
8. Gaoliang Ouyang(#)(*), Min Liu(#), Kai Ruan, Gang Song, Yubin Mao, Shideng Bao. Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway. Cancer Lett. , 2009; 281(2): 213-219. (影响因子: 3.504)
9. Ruichuan Chen(#)(*), Min Liu(#), Huan Li(#), Yuhua Xue, Wanichaya N Ramey, Nanhai He, Nanping Ai, Haohong Luo, Ying Zhu, Nan Zhou, Qiang Zhou(*). PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. , 2008; 22(10): 1356-1368. (影响因子: 14.795)
10. Xu Wang(#), Hao-Yan Wang(#), Guo-Sheng Hu(#), Wen-Shuai Tang, Li Weng, Yuzhu Zhang, Huiling Guo, Shan-Shan Yao, Shen-Ying Liu, Guo-Liang Zhang, Yan Han, Min Liu, Xiao-Dong Zhang, Xiang Cen, Hai-Feng Shen, Nengming Xiao, Chang-Qin Liu, Hong-Rui Wang, Jing Huang, Wen Liu, Peng Li, Tong-Jin Zhao(*). DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep. 2021, 35, 109281.
11. Ruicong Wang(#), Hongda Li(#), Jianfeng Wu(#), Zhi-Yu Cai(#), Baizhou Li, Hengxiao Ni, Xingfeng Qiu, Hui Chen, Wei Liu, Zhang-Hua Yang, Min Liu, Jin Hu, Yaoji Liang, Ping Lan, Jiahuai Han(*), Wei Mo(*). Gut stem cell necroptosis by genome instability triggers bowel inflammation. Nature 2020, 580:386–390.
12. Zhixiong Liu(#), Minbiao Yan(#), Yaoji Liang(#), Min Liu, Kun Zhang, Dandan Shao, Rencai Jiang, Li Li, Chaomeng Wang, Daniel R. Nussenzveig, Kunkun Zhang, Shaoxuan Chen, Chuanqi Zhong, Wei Mo, Beatriz M.A. Fontoura, Liang Zhang(*). Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination. Neuron 2019, 102(3):587-601.
13. You Li(#), Min Liu, Lin-Feng Chen, Ruichuan Chen(*),P-TEFb: finding its ways to release promoter-proximally paused RNA Polymerase II. Transcription. 2018, 9(2): 88-94.(Review) 受邀撰写
14. Zhimin Ou(#), Yuxia Sun(#), Li Lin(#), Nachun You, Xue Liu, Hongchao Li, Yanchen Ma, Lei Cao, Ying Han, Min Liu, Yaqi Deng, Luming Yao, Q. Richard Lu and Ying Chen(*). Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. J Neurosci. , 2016 Oct 12; 36(41):10560-10573.
15. Nanhai He(#), Caleb K Chan, Bijan Sobhian, Seemay Chou, Yuhua Xue, Min Liu, Tom Alber, Monsef Benkirane, Qiang Zhou(*). Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A, 108(36), E636-645, 2011.
16. Ruichuan Chen(#), Min Liu, Kai Zhang, Qiang Zhou(*). Isolation and functional characterization of P-TEFb-associated factors that control general and HIV-1 transcriptional elongation. Methods, 2011; 53(1): 85-90.
17. Nanhai He(#), Min Liu, Joanne Hsu, Yuhua Xue, Seemay Chou, Alma Burlingame, Nevan J Krogan, Tom Alber, Qiang Zhou(*). HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell, 38(3), 428-438, 2010.
18. Yubin Mao(#), Gang Song, Qiufeng Cai, Min Liu, Haohong Luo, Mingxin Shi, Gaoliang Ouyang(*), Shideng Bao. Hydrogen peroxide-induced apoptosis in human gastric carcinoma MGC803 cells. Cell Biol Int. 2006; 30(4):332-337.
19. Gao-Liang Ouyang(#), Qiu-Feng Cai, Min Liu, Rui-Chuan Chen, Zhi Huang, Rui-Sheng Jiang, Fu Chen, Shui-Gen Hong, Shi-Deng Bao(*). Growth arrest and apoptosis of human hepatocellular carcinoma cells induced by hexamethylene bisacetamide. World J Gastroenterol., 2004; 10(7): 954-958.
20. Bao S, Ouyang GL, Bai XF, Huang Z, Ma CY, Liu M, Shao R, Anderson RM, Rich JN, Wang XF. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339.

荣誉、奖励及参加学术团体的情况: