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陈霁云助理教授

邮  箱:chenjiyun@xmu.edu.cn

职称/职务:助理教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2014年,北京大学基础医学专业,学士学位;
2017年,北京大学生物物理学专业,博士学位;
2017-2020年,北京大学医学部,博士后;
2020年至今,澳门大阳城集团澳门大阳城集团2138网站,助理教授。
B.S. 2014, Peking University, Basic Medical Sciences;
Ph.D. 2017, Peking University, Biophysics;
Postdoctoral Fellow, Peking University Health Science Center, 2017-2020;
Assistant Professor, School of Life Sciences, Xiamen University, 2020 to Present.

RNA解旋酶介导的基因表达与调控的结构生物学研究。
Structural studies of RNA helicases mediated gene expression and regulation.

代表性论文(# co-first author, * Corresponding author):

1. Wang J#, Chen J#, Wu G#, Zhang H#, Du X#, Chen S, Zhang L, Wang K, Wu X, Gao S, Zhang S, Kuai B, Zhao P, Chi B, Wang L, Li G, Wong CCL, Zhou Y, Li J, Yun C, Cheng H. NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction. Genes Dev. 2019 Mar 6. doi: 10.1101/gad.322602.118.
2. Chen JY, Liu L, Cao CL, Li MJ, Tan K, Yang X, Yun CH. Structure and function of human Naa60 (NatF), a Golgi-localized bi-functional acetyltransferase. Sci Rep. 2016 Aug 23;6:31425. doi: 10.1038/srep31425.(IF2016=4.259)
3. Liu L#, Chen JY#, Yang B, Wang FH, Wang YH, Yun CH. Active-State Structures of a Small Heat-Shock Protein Revealed a Molecular Switch for Chaperone Function. Structure. 2015 Nov 3;23(11):2066-75. doi: 10.1016/j.str.2015.08.015.
4. Zhao P, Yao MY, Zhu SJ, Chen JY, Yun CH. Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul 20;502(3):332-337. doi: 10.1016/j.bbrc.2018.05.154.
5. Shi Y, Fan S, Wang D, Huyan T, Chen J, Chen J, Su J, Li X, Wang Z, Xie S, Yun C, Li X, Tie L. FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission. Biochim Biophys Acta. 2018 Jul; 1864(7):2481-2494. doi: 10.1016/j.bbadis. 2018.04.005.
6. Liu F, Wang B, Wang Q, Qi Z, Chen C, Kong LL, Chen JY, Liu X, Wang A, Hu C, Wang W, Wang H, Wu F, Ruan Y, Qi S, Liu J, Zou F, Hu Z, Wang W, Wang L, Zhang S, Yun CH, Zhai Z, Liu J, Liu Q. Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML). Oncotarget. 2016 Jun 14. doi: 10.18632/oncotarget.10037.
7. Liu L, Chen J, Yang B, Wang Y. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015 Mar 6;458(2):429-34.
8. Liu L, Chen J, Yang B, Wang Y. Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions. FEBS Open Bio. 2015 Mar 5;5:155-62.

荣誉、奖励及参加学术团体的情况: