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周化民教授

邮  箱:huaminzhou@xmu.edu.cn

职称/职务:教授

联系方式:+86-592-2187921

  • 个人简介
  • 科研领域
  • 代表性成果

1985年,安徽大学动物学专业,学士学位;
1987年,南京师范大学动物学专业,硕士学位;
1998年,中山大学动物学专业,博士学位;
1987-1995年,徐州师范大学生物系,助教/讲师;
1999-2002年,澳门大阳城集团,博士后;
2004-2005年,美国斯克利普斯研究所,访问学者;
2002年至今,澳门大阳城集团澳门大阳城集团2138网站,副教授/教授。
B.S. 1985, Anhui University, Zoology;
M.S. 1987, Nanjing Normal University, Zoology;
Ph.D. 1998, Sun Yat-Sen University, Zoology;
Teaching Assistant/Lecturer, Xuzhou Normal University, 1987-1995;
Postdoctoral Fellow, Xiamen University, 1999-2002;
Visiting Scholar, The Scripps Research Institute, 2004-2005;
Associate Professor/Professor, Xiamen University, 2002 to Present;

抗菌肽(antimicrobial peptide, AMP)是一类20-60个氨基酸组成的短肽,几乎在各类生物中均有发现,是先天性免疫的成份之一。三十多年的研究发现,AMP有广泛的活性,如抗菌、抗虫、免疫调节及抗肿瘤等。我们的研究兴趣在于AMP的抗肿瘤活性,主要研究AMP的结构、导致细胞死亡的机制、基于机制的肽类药物的设计与靶向传递,以便肽类抗肿瘤药物的开发。
Antimicrobial peptides (AMP) are a group of peptides with 20-60 amino acids and identifiedin almost all living organisms. These peptides are one of the components of innate immunity. In the past 30 years, it has been found that AMPs have extensive biological activities, such as anti-bacteria, anti-parasite, immune regulation and anti-tumor.Our research interest is in the antitumor activity of AMP, mainly including the structure of the AMP, its action mechanism leading to cell death, mechanism-based peptide design and targeted delivery, to developanti-tumor peptidedrug.

代表性论文(# co-first author, * Corresponding author):

1. Zhou Huamin, Sun Xuli, Chen Jianming*, Homologous Recombination and The Regulation of Recombinase Rad51. Progress in Biochemistry and Biophysics, 2016, 43(12): 1154~1162
2. Meng Xu, Chengfeng Cai, Xuli Sun, Wanze Chen, Qinxi Li*, Huamin Zhou*. Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.Biochem. Biophys. Res. Commun. , 2015, 463:275-279
3. Wu Xiaonan, Wang Xuekun, Wu Suqin, Lu J, Zheng Min, Wang Yanhan, Zhou Huamin, Zhang H, Han Jiahuai*, Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation, J Biol Chem. , 2011, 286(36):31501-11
4. Wei. Cheng, Chuanchao Song, K. M. Anjum, Mingliang Chen, Dongmei Li, Huamin. Zhou, Wei. Wang, Jianming Chen, Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity,International Journal of Immunogenetics,2011, 38:331-33,
5. Huamin Zhou, Jianming Chen, Jiahuai Han. Activation of p38 and determination of its activity. Methods Mol Biol.2010, 661:75-89.
6. Huamin Zhou*, Lin Yang, Hanjie Li, Linjie Li, Jianming Chen. Residues that affect human Argonaute2 concentration in cytoplasmic processing bodies. Biochem. Biophys. Res. Commun. 2009, 378:620–624
7. Qinxi Li, Na Zhang, Duanwu Zhang, Yuqian Wang, Tianwei Lin, Yanhai Wang, Huamin Zhou, Ziyun Ye, Shengcai Lin, Jiahuai Han*. Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes. J Biol Chem.2008, 283(16):11014-11023
8. Ziqiang Yang, Wei Cheng, Lixin Hong, Shengcai Lin, Jiahuai Han, Huamin Zhou* and Jun Gu*. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor-induced apoptosis of MCF-7 cells. Mol Biol Cell,2007, 18(11):4681-4689
9. Huamin Zhou, Zheng Min, Jianming Chen, Changchuan Xie, Anand R. Kolatkar, Tyler Zarubin, Zhiyun Ye, Radha Akella, Shengcai Lin, Elizabeth J. Goldsmith and Jiahuai Han*. Determinants that Control the Specific Interactions between TAB1 and p38α. Mol. Cell Biol. , 2006, 26 (10):3824-3834
10. Jean da Silva Correia, Yvonne Miranda, Nikki Austin-Brown, Jenny Hsu, John Mathison, Rong Xiang, Huamin Zhou, Qinxi Li, Jiahuai Han, and Richard J. Ulevitch*. Nod1-dependent control of tumor growth. PNAS.2006,103(6):1840–1845
11. Changchuan Xie, Na Zhang, Huamin Zhou, Jinquan Li, Qinxi Li, Tyler Zarubin, Sheng-Cai Lin and Jiahuai Han*. Distinct Roles of Basal Steady-State and Induced H-Ferritin in Tumor Necrosis Factor-Induced Death in L929 Cells. Mol. Cell Biol. 2005, 25:6673–6681
12. Huamin Zhou,Tyler Zarubin, Zhiliang Ji, Zheng Min, Wei Zhu, Jocelyn S. Downey, Shengcai Lin and Jiahuai Han*. Frequency and Distribution of AP-1 Sites in the Human Genome. DNA Res. 2005,12:139–150

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