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张亚霖教授博导

邮  箱:zhangyalin@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2008年,澳门大阳城集团生物科学专业,学士学位;
2013年,澳门大阳城集团生物化学与分子生物学专业,博士学位;
2014-2018年,美国爱因斯坦医学院博士后;
2018年至今,澳门大阳城集团澳门大阳城集团2138网站教授。
B.S. 2008, Xiamen University, Biological Sciences;
Ph.D. 2013, Xiamen University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Albert Einstein College of Medicine, 2014-2018;
Professor, School of Life Sciences, Xiamen University, 2018 to Present.

下丘脑是连接神经系统和内分泌系统的桥梁,具有食欲、血糖和体温等多个调节中枢,在维持机体内稳态中起关键作用。本课题组致力于研究下丘脑在机体能量代谢稳态以及衰老过程中的调控机制,重点关注神经系统炎症、神经内分泌因子和表观遗传在代谢综合征和神经退行性疾病中的功能。
The hypothalamus connects the neurological and endocrine systems, regulates appetite, glucose metabolism and body temperature, and plays a vital role in maintaining homeostasis. We focus on the mechanism of hypothalamic regulation of energy metabolism homeostasis and aging, especially the functions of neuroinflammation, neurosecretory and epigenetic factors in the development of metabolic syndrome and neurodegeneration.

代表性论文(# co-first author, * Corresponding author):

1. Zhang Y#, Kim MS#, Jia B#, Yan J#, Zuniga-Hertz JP, Han C, Cai D. Hypothalamic stem cells control aging speed partly through exosomal miRNAs. Nature. 2017 Aug 3;548(7665):52-57.
2. Zhang Y, Reichel JM, Han C, Zuniga-Hertz JP, Cai D. Astrocytic process plasticity and IKKβ/NF-κB in central control of blood glucose, blood pressure and body weight. Cell Metabolism. 2017 May 2;25(5):1091-1102.
3. Ale A, Zhang Y, Han C, Cai D. Obesity-associated extracellular mtDNA activates central TGFβ pathway to cause blood pressure increase. Am J Physiol Endocrinol Metab. 2016 Nov 15:ajpendo.00337.2016.
4. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature Immunology. 2015 May;16(5):525-33.
5. Zhang Y, Liu G, Yan J, Zhang Y, Li B, Cai D. Metabolic learning and memory formation by the brain influence systemic metabolic homeostasis. Nature Communications. 2015 Apr 7;6:6704.
6. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang Y, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC. The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism. 2014 Sep 2;20(3):526-40.
7. Zhang Y#, Guo H#, Zhang CS#, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, Lian G, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC. AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism. 2013 Oct 1;18(4):546-55.

荣誉、奖励及参加学术团体的情况: