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张宸崧教授博导

邮  箱:cszhang@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2184687

  • 个人简介
  • 科研领域
  • 代表性成果

2010年,澳门大阳城集团生物科学专业,学士学位;
2015年,澳门大阳城集团生物化学与分子生物学专业,博士学位;
2015年-2017年,澳门大阳城集团化学化工学院,博士后;
2017年-2019年,澳门大阳城集团澳门大阳城集团2138网站,博士后;
2019年至今,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 2010, Xiamen University, Biological Sciences;
Ph.D. 2015, Xiamen University, Biochemistry and Molecular Biology;
Post-doctor, College of Chemistry and Chemical Engineering, Xiamen University, 2015-2017;
Post-doctor, School of Life Sciences, Xiamen University, 2017-2019;
Professor, School of Life Sciences, Xiamen University, 2019 to Present.

研究营养物质的感应机制和其对机体代谢稳态的维持与调控的方式,以及在对生理和病理条件下代谢调控的枢纽蛋白,特别是代谢稳态核心调节蛋白AMPK的调控机制和生理功能的研究。

代表性论文(# co-first author, * Corresponding author):

1. Ma T, Tian X, Zhang BD, Li MQ, Wang Y, Yang CY, Wu JF, Wei XY, Qu Q, Yu YX, Long ST, Feng JW, Li C, Zhang, CX, Xie CC, Wu YU, Xu ZN, Chen JJ, Yu Y, Huang X, He Y, Yao LM, Zhang L, Zhu, MX, Wang W, Wang ZC, Zhang ML, Bao YQ, Jia WP, Lin SY, Ye ZY, Piao HL, Deng XM*, Zhang CS*, Lin SC*. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Nature, 603(7899)(2022), 159-165.
2. Zhang CS, Hardie DG*, Lin SC*. Glucose Starvation Blocks Translation at Multiple Levels. Cell Metabolism 31, 217-218, 2020.
3. Li MQ#, Zhang CS#, Zong Y#, Feng JW, et al., Lin SC*. Transient Receptor Potential V channels are essential for Glucose Sensing by Aldolase and AMPK. Cell Metabolism 30, 508–524, 2019. (IF=18.164)
4. Zong Y#, Zhang CS#, Li MQ, Wang W, Wang ZH, Simon A. H, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang CX, Ye ZY, Lin SY, Piao HL, D. G Hardie, Lin SC* Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress. Cell Research, 29:460–473, 2019
5. Cai WF, Zhang C1, Wu YQ, Zhuang G, Ye Z, Zhang CS*, and, Lin SC*. Glutaminase GLS1 senses glutamine in a nonenzymatic manner triggering mitochondrial fusion. Cell Research 28, 865–867, 2018 (IF: 17.85)
6. Zhang CS#, Hawley SA#, Zong Y#, Li MQ#, Wang ZC, Gray A, Ma T, Cui JW, Feng JW, Zhu MJ, Wu YQ, Li TY, Ye Z, Lin SY, Yin HY, Piao HL, Hardie DG*, Lin SC*. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature 548, 112-116, 2017 (IF=43.037)
7. Zhang CS#, Li M#, Ma T#, Zong Y, Cui J, Feng JW, Wu, YQ, Lin SY, and Lin SC*. Metformin activates AMPK through the lysosomal pathway. Cell Metabolism 24, 521-2, 2016 (IF=18.164)
8. Zhang CS, and Lin SC*. AMPK Promotes Mitophagy through Facilitating Mitochondrial Fission. Cell Metabolism 23, 399-341, 2016 (IF=18.164)
9. Zhang CS#, Liu Q#, Li MQ#, Lin SY#, Peng YY, Wu D, Li TY, Fu Q, Jia WP, Wang XJ, Ma T, Zong Y, Cui JW, Pu CF, Lian GL, Guo GL, Ye ZY, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIF1alpha through facilitating hydroxylation and suppresses the Warburg effect. Cell Res. 25, 1025-42, 2015 (IF=15.606)
10. Zhang CS#, Jiang B#,Li MQ#, Zhu MJ, Peng YY, Zhang YL, Wu YQ, Li TY, Liang Y, Lu ZL, Lian GL, Liu Q, Guo HL,Yin ZY, Ye ZY, Han J, Wu JW, Yin HY, Lin SY, Lin SC*. The Lysosomal v-ATPase-Ragulator Complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism. Cell Metabolism 20, 526-40, 2014 (IF=18.164)
11. Zhang YL#, Guo HL#, Zhang CS#, Lin SY, Li P, WU JW, and Lin SC*. AMP as a low energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metabolism 18, 546–555, 2013 (IF=18.164)

荣誉、奖励及参加学术团体的情况:

澳门大阳城集团南强青年拔尖人才(A类),2019年
中国生命科学十大进展,2017年
中国糖尿病十大研究,2017年
邹承鲁杰出研究论文奖,2017年
福建省优秀博士毕业论文,2017年
中国博士后科学基金面上资助,2016年
入选第一批中国科协青年人才托举项目,2016年