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王波教授博导

邮  箱:bowang@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2011年,华中科技大学生物技术专业,学士学位;
2016年,田纳西健康医学中心神经生物学专业,博士学位;
2019年,圣裘德儿童研究医院,博士后;
2020年,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 2011, Huazhong University of Science and Technology, Biotechnology;
PhD. 2016, the University of Tennessee Health Science Center, Neuroscience;
Postdoc., St. Jude Children’s Research Hospital, 2017-2019;
Professor, School of Life Sciences, Xiamen University, 2020 to Present.

阐述RNA代谢的细胞和分子机制,以及代谢紊乱如何导致退行性疾病, 比如ALS/FTD/IBM;深入阐释自噬在神经退行性疾病发生过程中所扮演的角色。
To elucidate the cellular and molecular mechanisms of RNA metabolism and how the dysfunction of RNA metabolism contributes to degenerative diseases, such as ALS/FTD/IBM;To uncover the role of autophagy in the pathogenesis of neurodegeneration.

代表性论文(# co-first author, * Corresponding author):

1. Wang, B., Maxwell, B., Joo, J.H., Gwon, Y., Messing, J., Mishra, A., Shaw, T., Ward, A., Quan, H., Sakurada, S.M., et al. (2019). ULK1/2 regulate stress granule disassembly through phosphorylation and activation of VCP. Mol Cell74, 1-16. (Cover story) *Highlighted in Williams ER. Turning off cellular stress. Sci Signal 12:eaax9738, 2019.
2. Wang, B., Joo, JH., Mount, R., Teubner, BJW., Krenzer, A., Ward, AL., Ichhaporia, VP., Elizabeth AJ., Khoriaty, R., Peters ST., et al. (2018). The COPII cargo adapter SEC24C is essential for neuronal homeostasis. J Clin Invest 128, 3319–3332.
3. Wang, B., Iyengar, R., Li-Harms, X., Joo, J.H., Wright, C., Lavado, A., Yang, M., Guan, JL., Green, DR., Cao, X., and Kundu, M. (2017). The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy 3, 1-16. (Cover story)
4. Wang, B. & Kundu, M. (2017). Canonical and noncanonical functions of ULK/Atg1. Curr. Opin. Cell Biol. 45, 47-54.
5. Joo, J.H.*, Wang, B.*, Frankel, E., Ge, L., Xu, L., Iyengar, R., Li-Harms, X., Wright, C., Shaw, T.I., Lindsten, T., et al. (2016). The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis. Mol Cell 62, 491-506. *authors contributed equally. (Cover story) *Highlighted in Zhao YG and Zhang H. The Incredible ULKs: Autophagy and Beyond. Mol Cell 63:475-476, 2016.*Highlighted in Strzyz P. The second job of ULKs. Nat Rev Mol Cell Biol 17:396–397, 2016.
6. Kim, N.C., Tresse, E., Kolaitis, R.M., Molliex, A., Thomas, R.E., Alami, N.H., Wang, B., Joshi, A., Smith, R.B., Ritson, G.P., et al. (2013). VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations. Neuron 78, 65-80.
7. Xiao, L., Wang, B., Yang, G., and Gauthier, G. (2012). Poly(Lactic Acid)-Based Biomaterials: Synthesis, Modification and Applications, Biomedical Science, Engineering and Technology, Dhanjoo N. Ghista (Ed.) , ISBN: 978-953-307-471-9.

荣誉、奖励及参加学术团体的情况: