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俞春东教授博导

邮  箱:cdyu@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

1993年,中山大学生物化学专业,学士学位;
1996年,澳门大阳城集团细胞生物学专业,硕士学位;
2002年,美国德州大学休斯敦健康科学中心细胞生物学专业,博士学位;
2002-2006年,美国贝勒医学院,博士后;
2006年,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 1993, Sun Yat-sen University, Biochemistry;
M.S. 1996, Xiamen University, Cell Biology;
Ph.D. 2002, University of Texas Health Science Center, Cell Biology;
Postdoctoral Fellow, Baylor College of Medicine, 2002-2006;
Professor, School of Life Sciences, Xiamen University, 2006.

炎症与胃肠病学课题组主要从事炎症感染以及消化道生理病理相关的理论和应用研究。本课题组主要有两个研究方向:第一,研究转录协同因子在炎症与感染中的作用。第二,研究转录协同因子在肝脏代谢及肝损伤、肝纤维化和肝癌等肝脏疾病以及肠炎和肠癌等肠道疾病中的作用。
Laboratory of Inflammation and Gastroenternology is mainly engaged in the theoretical and applied research related to the physiology and pathology of inflammation, infection, and gastrointestine. Our research group has two main research focuses: first, to study the role of transcriptional coregulators in inflammation and infection. Second, to study the role of transcriptional coregulators in liver metabolism and liver diseases such as liver injury, liver fibrosis, and liver cancer, as well as intestinal diseases such as enteritis and colorectal cancer.

代表性论文(# co-first author, * Corresponding author):

1. Guo P#, Chen Q#, Peng K#, Xie J, Liu J, Ren W, Tong Z, Li M, Xu J, Zhang Y*, Yu C*, Mo P*. Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling. Oncogene. 2022;41(20):2846-2859.
2. Chen Q, Zhuang S, Hong Y, Yang L, Guo P, Mo P, Peng K*, Li W*, Xiao N*, Yu C*. Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling. Oncogene. 2022;41(10):1421-1433.
3. Deng Y#, Li M#, Zhuo M, Guo P, Chen Q, Mo P, Li W*, Yu C*. Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. J Biol Chem. 2021;296:100121.
4. Peng K#, Zhuo M#, Li M, Chen Q, Mo P*, Yu C*. Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. Oncogene. 2020;39(47):7076-7091.
5. Li M#, Deng Y#, Zhuo M, Zhou H, Kong X, Xia X, Su Z, Chen Q, Guo P, Mo P, Yu C*, Li W*. Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote liver cancer initiation and progression. Theranostics. 2020;10(19):8863-8879.
6. Zhuo M#, Chen W#, Shang S, Guo P, Peng K, Li M, Mo P, Zhang Y, Qiu X*, Li W*, Yu C*. Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. Oncogene. 2020;39(16):3336-3353
7. Peng K, Kou L, Yu L, Bai C, Li M, Mo P, Li W*, Yu C*. Histone demethylase JMJD2D interacts with -catenin to induce transcription and activate colorectal cancer cell proliferation and tumor growth in mice. Gastroenterology. 2019;16:1112-1126.
8. Peng K#, Su G#, Ji J, Yang X, Miao M, Mo P, Li M, Xu J, Li W*, Yu C*. Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing wnt/β-catenin signaling. J Biol Chem. 2018;293(27):10606-10619.
9. Wan W#, Peng K#, Li M, Qin L, Tong Z, Yan J, Shen B, Yu C* (2017). Histone demethylase JMJD1A promotes urinary bladder cancer progression by enhancing glycolysis through coactivation of hypoxia inducible factor 1α. Oncogene. 2017;36: 3868–3877.
10. Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C*. Steroid receptor coactivator 3 contributes to host defense against enteric bacteria by recruiting neutrophils via upregulation of CXCL2 expression. J Immunol. 2017;198(4):1606-1615.
11. Tong Z, Li M, Wang W, Mo P, Yu L, Liu K, Ren W, Li W, Zhang H, Xu J, Yu C*. Steroid receptor coactivator 1 promotes human hepatocellular carcinoma progression by enhancing wnt/beta-catenin signaling. J Biol Chem. 2015;290:18596-18608.
12. Mo P, Zhou Q, Guan L, Wang Y, Wang W, Miao M, Tong Z, Li M, Majaz S, Liu Y, Su G, Xu J, Yu C*. Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing notch signaling. Oncogene. 2015;34:3935-3945.
13. Liu Y, Tong Z, Li T, Chen Q, Zhuo L, Li W, Wu R-C, Yu C*. Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasiveness. Hepatology. 2012;56(3):1015-1024.
14. Chen Q, Li W, Wan Y, Xia X, Wu Q, Chen Y, Lai Z, Yu C*, Li W*. Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways. Hepatology. 2012;55:1820-1829.
15. Chen T, Chen Q, Xu Y, Zhou Q, Zhu J, Zhang H, Wu Q, Yu C*. Steroid receptor coactivator 3 is required for CAR-regulated hepatocyte proliferation and drug metabolism. J Hepatol. 2012;56:210-217.

荣誉、奖励及参加学术团体的情况:

教育部新世纪优秀人才支持计划入选者,2010年
福建省自然科学基金杰出青年基金获得者,2011年