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曾涛玲助理教授

邮  箱:zengtaoling@xmu.edu.cn

职称/职务:助理教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2009年,西南大学生物科学专业,学士学位;
2014年,澳门大阳城集团细胞生物学专业,博士学位;
2015-2019年,澳门大阳城集团澳门大阳城集团2138网站,工程师;
2019年,澳门大阳城集团澳门大阳城集团2138网站,助理教授。
B.S. 2009, Southwest University, Biological Sciences;
Ph.D. 2014, Xiamen University, Cell Biology;
Engineer, School of Life Sciences, Xiamen University, 2015-2019;
Assistant Professor, School of Life Sciences, Xiamen University, 2019 to Present.

蛋白翻译后修饰与肿瘤发生发展:蛋白质的泛素化和类泛素化修饰对于调节各种细胞和机体生物学活性都起着十分重要的作用,其调控的紊乱会导致包括神经退行性疾病和癌症在内的多种重大疾病的发生。我们致力于研究蛋白质泛素化和类泛素化修饰在调控细胞生长、死亡、自噬以及肿瘤发生发展中的作用和分子机理。同时,在分子机理研究的基础上,以在肿瘤发生发展中起重要作用的泛素连接酶为靶点,进行抗肿瘤新型靶向药物的研发,以期获得癌症治疗的新的先导化合物。
Protein post-translational modifications such as ubiquitination and ubiquitin-like modification are key regulatory mechanisms that control various biological processes. Dysregulation of protein modification results in development of many human diseases like neurodegenerative disease and cancer. Our research interest has been focused on mechanism studies of ubiquitination and ubiquitin-like modification in regulation of cell proliferation, cell death, autophagy, and tumorigenesis. We are also working on identifying small-molecule modulators of E3 ubiquitin ligases that are critical for cancer development, which is emerging as a promising drug discovery strategy.

代表性论文(# co-first author, * Corresponding author):

1. Maoyuan Tian#,Taoling Zeng#, Mingdong Liu, Shang Han, Huayue Lin, Qi Lin, Li Li, Tingting Jiang, Gao Li, Hong Lin, Ting Zhang, Qiaofeng Kang, Xianming Deng*, Hong-Rui Wang*. A cell-based high-throughput screening method for modulators of E3 ligases using ubiquitin-reference-technique (URT) technique. J Biol Chem, 2019, 294(8): 2880-2891.
2. Mingdong Liu#,Taoling Zeng#, Xin Zhang#, Chunyan Liu, Zhihui Wu, Luming Yao, Changchuan Xie, Hui Xia, Qi Lin, Liping Xie, Dawang Zhou, Xianming Deng, Hong-Lin Chan, Tong-Jin Zhao*, Hong-Rui Wang*.ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage. Nature Communications, 2018, 9:4139.
3. Zeng T#, Wang Q#, Fu J#, Lin Q, Bi J, Ding W, Qiao Y, Zhang S, Zhao W, Lin H,Wang M, Lu B, Deng X, Zhou D, Yin Z*, Wang HR*.Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis. Cell Reports, 2014,7(3):871-82.
4. Wang M#, Guo L#, Wu Q#,Zeng T, Lin Q, Qiao Y, Wang Q, Liu M, Zhang X, RenL, Zhang S, Pei Y, Yin Z, Ding F, Wang HR*.ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance. Nature Communications, 2014, 5:4901.

荣誉、奖励及参加学术团体的情况: