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苏冬雪助理教授

邮  箱:sudongxue@xmu.edu.cn

职称/职务:特任副研究员

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2014年,华侨大学生物技术专业,学士学位;
2019年,首都医科大学生化与分子生物学专业,博士学位;
2019年至今,澳门大阳城集团澳门大阳城集团2138网站,助理教授;
2021年至今,澳门大阳城集团澳门大阳城集团2138网站,特任副研究员。
B.S. 2014, Huaqiao University, Biotechnology;
Ph.D. 2019, Capital Medical University, Biochemistry and Molecular Biology;
Assistant Professor, School of Life Sciences, Xiamen University, 2019 to Present;
Special Associate Researcher, School of Life Sciences, Xiamen University, 2021 to Present.

Dr. Dongxue Su’s previous work was focus on DNA damage response and gene transcription regulation. She now works as an assistant professor in Dawang Zhou’s Lab. The Hippo pathway has emerged as a critical developmental pathway contributing to processes that regulate tissue growth and organ size. Our research group aims to characterize the regulation and physiologic functions of the Mst1 and Mst2 protein kinases, which are the mammalian orthologs of the “hippo” kinase. The identification of the molecular elements upstream and downstream of the Mst1/2 kinases for each of these functions is the focus of present effort.

代表性论文(# co-first author, * Corresponding author):

1. Dongxue Su#, Wenjuan Wang, Yongqiang Hou, Liyong Wang, Xianfu Yi, Cheng Cao, Yuejiao Wang, Yue Wang, Chao Yang, Beibei Liu, Xing Chen, Xiaodi Wu, Jiajing Wu, Dong Yan, Shuqi Wei, Lulu Han, Shumeng Liu, Qian Wang, Lei Shi, and Lin Shan*. Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis. Nucleic Acids Research. 2021;49(8):4421-4440.
2. Dongxue Su#, Shuai Ma#, Lin Shan, Yue Wang, Yuejiao Wang, Cheng Cao, Beibei Liu, Chao Yang, Liyong Wang, Shanshan Tian, Xiang Ding, Xinhua Liu, Na Yu, Nan Song, Ling Liu, Shangda Yang, Qi Zhang, Fuquan Yang, Kai Zhang, and Lei Shi*. Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis. J Clin Invest. 2018 Oct 1;128(10):4280-4296.
3. Shuai Ma#, Cheng Cao#, Shiyou Che#, Yuejiao Wang#, Dongxue Su#, Shuai Liu, Wenchen Gong, Ling Liu, Jixue Sun, Jiao Zhao, Qian Wang, Nan Song, Tong Ge, Qiushi Guo, Shanshan Tian, Charlie Degui Chen, Tao Zhang, Ju Wang, Xiang Ding, Fuquan Yang, Guoguang Ying, Jie Yang, Kai Zhang, Yi Zhu, Zhi Yao*, Na Yang*, Lei Shi*. PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability. Science Advances. 2021; 7(19): eabf7684.
4. Xin Li#, Nan Song#, Ling Liu, Xinhua Liu, Xiang Ding, Xin Song, Shangda Yang, Lin Shan, Xing Zhou, Dongxue Su, Yue Wang, Qi Zhang, Cheng Cao, Shuai Ma, Na Yu, Fuquan Yang, Yan Wang, Zhi Yao, Yongfeng Shang* & Lei Shi*. USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun. 2017 Mar 31;8:14866. doi: 10.1038/ncomms14866.
5. Yang Duan, Dawei Huo, Jie Gao, Heng Wu, Zheng Ye, Zhe Liu, Kai Zhang, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Xiang Ding, Lei Shi, Yan Wang, Yongfeng Shang* &Chenghao Xuan*. Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5. Nat Commun. 2016 Aug 25;7:12648. doi: 10.1038/ncomms12648.
6. Qian Wang#, Shuai Ma#, Nan Song, Xin Li, Ling Liu, Shangda Yang, Xiang Ding, Lin Shan, Xing Zhou, Dongxue Su, Yue Wang, Qi Zhang, Xinhua Liu, Na Yu, Kai Zhang, Yongfeng Shang, Zhi Yao, and Lei Shi*. Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis. J Clin Invest. 2016; 126(6):2205–2220.
7. Lin Shan, Xing Zhou, Xinhua Liu, Yue Wang, Dongxue Su, Yongqiang Hou, Na Yu, Chao Yang, Beibei Liu, Jie Gao, Yang Duan, Jianguo Yang, Wanjin Li, Jing Liang, Luyang Sun, Kexin Chen, Chenghao Xuan, Lei Shi, Yan Wang, and Yongfeng Shang*. FOXK2 Elicits Massive Transcription Repression and Suppresses the Hypoxic Response and Breast Cancer Carcinogenesis. Cancer Cell, 2016 Nov 14; 30(5):708-722.
8. Wenzhe Si, Wei Huang, Yu Zheng, Yang Yang, Xujun Liu, Lin Shan, Xing Zhou, Yue Wang, Dongxue Su, Jie Gao, Ruorong Yan, Xiao Han, Wanjin Li, Lin He, Lei Shi, Chenghao Xuan, Jing Liang, Luyang Sun, Yan Wang*, and Yongfeng Shang*. Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis. Cancer Cell, 2015 Jun 8, 27(6): 822~836.

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