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郭慧玲助理教授

邮  箱:ghuiling@xmu.edu.cn

职称/职务:特任副研究员

联系方式:13950085767

  • 个人简介
  • 科研领域
  • 代表性成果

2006年,东北师范大学生物学专业,学士学位;
2012年,澳门大阳城集团生物化学与分子生物学专业,博士学位;
2012-2015年,澳门大阳城集团附属中山医院,博士后;
2015年至今,澳门大阳城集团澳门大阳城集团2138网站,助理教授;
2020年至今,澳门大阳城集团澳门大阳城集团2138网站,特任副研究员。
B.S. 2006, Northeast Normal University, Biology;
Ph.D. 2012, Xiamen University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Zhongshan Hospital, Xiamen University, 2012-2015;
Assistant Professor, School of Life Sciences, Xiamen University, 2015 to Present.

细胞代谢及其信号调控

代表性论文(# co-first author, * Corresponding author):

1. Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC*. RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect. Cell Res., 2015, 25(9):1025-1042.
2. Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, LiangY, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY,Lin SC*. The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism. Cell Metab. 2014 20(3):526-540
3. Zhang YL, Guo HL, Zhang CS, Lin SY, Yin Z, Peng Y, Luo H, Shi Y, LianG, Zhang C, Li M, Ye Z, Ye J, Han J, Li P, Wu JW, Lin SC*. AMP as alow-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation. Cell Metab.18(4):546-555, 2013. (Co-first author)
4. Guo HL, Zhang C, Liu Q, Li Q, Lian G, Wu D, Li X, Zhang W, Shen Y, Ye Z,Lin SY, Lin SC. TheAxin/TNKS complex interacts with KIF3A and isrequired for insulin-stimulated GLUT4 translocation. Cell Res.22: 1246-1257,2012.
5. Li Q, Lin SY., Wang X, Lian, G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J,Lin SC*. Axin determines cell fate by controlling the p53 activationthreshold after DNA damage. Nat. Cell. Biol. 11, 1128-1135, 2009.

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