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陈鑫副教授博导

邮  箱:threegold@xmu.edu.cn

职称/职务:副教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2006年,澳门大阳城集团生物科学专业,学士学位;
2011年,中国科学院上海生命科学研究院生物化学与分子生物学专业,博士学位;
2011-2018年,澳门大阳城集团澳门大阳城集团2138网站,博士后;
2018年至今,澳门大阳城集团澳门大阳城集团2138网站,副教授.
B.S. 2006, Xiamen University, Biological Sciences;
Ph.D. 2011, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Xiamen University, 2011-2018;
Associate Professor, School of Life Sciences, Xiamen University, 2018 to Present.

在多种生理病理条件下精确地看到分子复合物或细胞结构组织方式,对于我们揭示生命奥秘具有至关重要的意义。我们应用并发展多种超分辨显微成像策略,描绘特定生物系统中纳米尺度上的功能图谱。近期我们将聚焦细胞程序性死亡,也将对诸如肿瘤免疫、代谢稳态和器官发育等多种重要科学问题开展探索和研究。
To precisely visualize the organization of molecular complexes and cellular structures under physiological or pathological conditions, is extremely important for us to better uncover the secret of life. We are applying and developing multiple approaches based on super-resolution microscopy to paint a functional map with nanometer scale for a certain biological system. We now focus on programmed cell death and are also interested in studying many other biological topics, such as cancer immunity, metabolism homeostasis, and organ development.

代表性论文(# co-first author, * Corresponding author):

1. Chen X*, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J*. Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death. Nat Cell Biol. 2022 Apr;24(4):471-482.
2. Xue Z, Wang S, Li J, Chen X*, Han J, Han S*. Bifunctional Super-resolution Imaging Probe with Acidity-independent Lysosome-retention Mechanism. Anal Chem. 2018 Oct 2;90(19):11393-11400.
3. Chen X#, He WT#, Hu L, Li J, Fang Y, Wang X, Xu X, Wang Z, Huang K, Han J*. Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res. 2016 Sep;26(9):1007-20.
4. Chen X#, Li W#, Ren J#, Huang D, He WT, Song Y, Yang C, Li W, Zheng X, Chen P, Han J*. Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death. Cell Res. 2014 Jan;24(1):105-21. This article was highlighted by Cell Res, recommended by Faculty of 1000 Biology, and regarded as a highly cited paper by Web of Science.
5. Chen X#, Ma JJ#, Tan M, Yao P, Hu QH, Eriani G, Wang ED*. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Res. 2011 Jan;39(1):235-47.
6. Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q. Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis. Mol Cell. 2022 May 19;82(10):1821-1835.e6.
7. Zhou X#, Ma F#, Xie J#, Yuan M#, Li Y#, Shaabani N#, Zhao F, Huang D, Wu NC, Lee CD, Liu H, Li J, Chen Z, Hong Y, Liu WH, Xiao N, Burton DR, Tu H, Li H, Chen X, Teijaro JR, Wilson IA*, Xiao C*, Huang Z*. Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2. Cell Rep. 2021 May 11;35(6):109109.
8. Li M#, Zhang CS#, Zong Y#, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC*. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;30(3):508-524.e12.
9. Gao H#, Yang Z#, Wang X#, Qian P, Hong R, Chen X, Su XZ, Cui H, Yuan J*. ISP1-Anchored Polarization of GCβ/CDC50A Complex Initiates Malaria Ookinete Gliding Motility. Curr Biol. 2018;28(17):2763–2776.e6.
10. Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J*. RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 2018 Feb;20(2):186-197.
11. Zhang Y, Chen X, Gueydan C, Han J*. Plasma membrane changes during programmed cell deaths. Cell Res. 2018 Jan;28(1):9-21.

荣誉、奖励及参加学术团体的情况:

入选中国细胞生物学学会细胞死亡研究分会首届委员(2020-2023)