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周大旺教授博导

邮  箱:dwzhou@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2186353

  • 个人简介
  • 科研领域
  • 代表性成果

1998年,澳门大阳城集团有机化学专业,学士学位;
2002年,美国纽约城市大学生物化学专业,硕士学位;
2006年,美国耶希瓦大学微生物与免疫学专业,博士学位;
2006-2011年,哈佛大学医学院,博士后/讲师;
2011年至今,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 1998, Xiamen University, Organic Chemistry;
M.S. 2002, The City University of New York, Biochemistry;
Ph.D. 2006, Yeshiva University, Microbiology and Immunology;
Postdoctoral Fellow/Instructor in Medicine, Harvard Medical School, 2006-2011;
Professor, School of Life Sciences, Xiamen University, 2011 to Present.

长期从事Hippo信号通路的生物学功能和调控机制研究,探究其失控导致免疫失调、癌症发生等疾病的致病机理和靶向干预的策略,聚焦损伤组织的修复再生和尺寸大小如何调控的科学问题开展了系列研究:揭示Hippo信号通路是高等生物中调控器官再生和大小的关键性通路,系统解析该通路在细胞增殖、凋亡、分化及稳态维持等细胞生命活动中的功能及其调控机制,阐明该通路失调导致组织衰竭、肿瘤和免疫疾病发生的致病机理,筛选获得靶向Hippo蛋白激酶Mst1/2的小分子抑制剂(XMU-MP-1),可有效促进肝脏和肠道的修复与再生,已获得专利。
The Hippo pathway has emerged as a critical developmental pathway contributing to processes that regulate tissue growth and organ size. Our research group aims to characterize the regulation and physiologic functions of the Mst1 and Mst2 protein kinases, which are the mammalian orthologs of the “hippo” kinase. Recently, we have made several exciting discoveries regarding the physiological functions of these two kinases. The liver phenotype reflects an essential, overlapping function of Mst1 and Mst2 in the negative regulation of liver cell proliferation, whereas the lymphocyte cell phenotype reflects predominantly the loss of Mst1/2-mediated regulation of cell adhesion and migration. The identification of the molecular elements upstream and downstream of the Mst1/2 kinases for each of these functions is the focus of present effort.

代表性论文(# co-first author, * Corresponding author):

1. Qingxu Liu#; Jiaxin Li#; Weiji Zhang#; Chen Xiao#; Shihao Zhang#; Cheng Nian; Junhong Li; Dongxue Su; Lihong Chen; Qian Zhao; Hui Shao; Hao Zhao; Qinghua Chen; Yuxi Li; Jing Geng; Lixin Hong; Shuhai Lin; Qiao Wu; Xianming Deng; Rongqin Ke; Jin Ding; Randy L. Johnson; Xiaolong Liu; Lanfen Chen*; Dawang Zhou*. Glycogen accumulation and phase separation drives liver tumor initiation. Cell. 2021 Oct 28; 184(22):5559-5576.e19.
2. Jing Geng#; Yiran Shi#; Jinjia Zhang#; Bingying Yang; Ping Wang; Weihong Yuan; Hao Zhao; Junhong Li; Funiu Qin; Lixin Hong; Changchuan Xie; Xianming Deng; Yujie Sun; Congying Wu; Lanfen Chen*; Dawang Zhou*. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection. Nature Communications. 2021 Jun 10, 12(1):3519.
3. Suyuan Ji#; Qingxu Liu#; Shihao Zhang#; Qinghua Chen#; Cong Wang#; Weiji Zhang; Chen Xiao; Yuxi Li; Cheng Nian; Jiaxin Li; Junhong Li; Jing Geng; Lixin Hong; Changchuan Xie; Ying He; Xing Chen; Xun Li; Zhen-Yu Yin; Han You; Kwang-Huei Lin; Qiao Wu; Chundong Yu; Randy L. Johnson; Li Wang; Lanfen Chen; Fen Wang; Dawang Zhou*. FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis. Developmental Cell. 2019 Feb 25; 48(4):460-474.e9.
4. Shihao Zhang#; Qinghua Chen#; Qingxu Liu#;Yuxi Li; Xiufeng Sun; Lixin Hong; Suyuan Ji; Chenyan Liu; Jing Geng; Weiji Zhang; Zhonglei Lu; Zhen-Yu Yin; Yuanyuan Zeng; Kwang-Huei Lin; Qiao Wu; Qiyuan Li; Keiko Nakayama; Keiich I Nakayama; Xianming Deng; Randy L Johnson; Liang Zhu; Daming Gao; Lanfen Chen*; Dawang Zhou*. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. Cancer Cell. 2017 May 8; 31(5):669-684.e7.
5. Jing Geng#; Shujuan Yu#; Hao Zhao#; Xiufeng Sun#; Xun Li; Ping Wang; Xiaolin Xiong; Lixin Hong; Changchuan Xie; Jiahui Gao; Yiran Shi; Jiaqi Peng; Randy L Johnson; Nengming Xiao; Linrong Lu; Jiahuai Han; Dawang Zhou*; Lanfen Chen*. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nature Immunology. 2017 Jul; 18(7):800-812.
6. Fuqin Fan#; Zhixiang He#; Lu-Lu Kong#; Qinghua Chen#; Quan Yuan#; Shihao Zhang; Jinjin Ye; Hao Liu; Xiufeng Sun; Jing Geng; Lunzhi Yuan; Lixin Hong; Chen Xiao; Weiji Zhang; Xihuan Sun; Yunzhan Li; Ping Wang; Lihong Huang; Xinrui Wu; Zhiliang Ji; Qiao Wu; Ning-Shao Xia; Nathanael S Gray; Lanfen Chen; Cai-Hong Yun*; Xianming Deng*; Dawang Zhou*. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. Science Translational Medicine. 2016 Aug 17; 8(352):352ra108.
7. Jing Geng#; Xiufeng Sun#; Ping Wang; Shihao Zhang; Xiaozhen Wang;Hongtan Wu; Lixin Hong; Changchuan Xie;Xun Li; Hao Zhao; Qingxu Liu; Mingting Jiang; Qinghua Chen; Jinjia Zhang;, Yang Li; Siyang Song; Hong-Rui Wang; Rongbin Zhou; Randy L Johnson; Kun-Yi Chien; Sheng-Cai Lin; Jiahuai Han; Joseph Avruch; Lanfen Chen*; Dawang Zhou*. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature Immunology. 2015 Nov; 16(11):1142-52.
8. Hongtan Wu#; Luyao Wei#; Fuqin Fan#; Suyuan Ji#; Shihao Zhang; Jing Geng; Lixin Hong; Xin Fan; Qinghua Chen; Jing Tian; Mingting Jiang; Xiufeng Sun; Changnan Jin; Zhen-Yu Yin; Qingxu Liu; Jinjia Zhang; Funiu Qin; Kwang-Huei Lin; Jau-Song Yu; Xianming Deng; Hong-Rui Wang; Bin Zhao; Randy L Johnson; Lanfen Chen*; Dawang Zhou*. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nature Communications. 2015 Feb 19; 6:6239.
9. Hongtan Wu#; Yubo Xiao#; Shihao Zhang#; Suyuan Ji; Luyao Wei; Fuqin Fan; Jing Geng; Jing Tian; Xiufeng Sun; Funiu Qin; Changnan Jin; Jianjun Lin; Zhen-Yu Yin; Ting Zhang; Lianzhong Luo; Yang Li; Siyang Song; Sheng-Cai Lin,; Xianming Deng; Fernando Camargo; Joseph Avruch; Lanfen Chen* and Dawang Zhou*. The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense. Cell Reports. 2013 May 30; 3:1663-1677.
10. Fan Mou; Maria Praskova; Fan Xia; Denille Van Buren; Hanno Hock; Joseph Avruch*; Dawang Zhou*. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. Journal of Experimental Medicine. 2012 Apr 9; 209(4):741-59.

荣誉、奖励及参加学术团体的情况:

福建省自然科学一等奖,2020年
创新研究群体项目(负责人),2020年
政府特殊津贴专家,2019年
国家“万人计划”,2019年
第七届“中国侨界贡献奖”,2018年
长江学者奖励计划,2018年
普洛麦格创新奖,2017年
国家重点研发计划项目(首席科学家),2017年
中青年科技创新领军人才,2017年
国家杰出青年科学基金,2016年
参加的主要学术团体:
Disease Models & Mechanisms,Editorial Board
Cancers,Editorial Board
Life Medicine,Editorial Board
教育部高等学校生物技术、生物工程类专业教学指导委员会,委员
国家千人计划生物医药与生命科学专业委员会,副主任
中国生物化学与分子生物学会,常务理事
中国细胞生物学学会,理事
中国病理生理学会,理事
中国Hippo研究联盟,发起人、委员
中国免疫学会青年工作委员会,副主任委员
中国细胞生物学学会-发育生物学分会,副会长
中国细胞生物学学会-细胞信号转导分会,副会长
中国细胞生物学学会-细胞代谢分会,副会长