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尤涵教授博导

邮  箱:hyou@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

1999年,第四军医大学临床医疗专业,学士/硕士学位;
2002年,第四军医大学临床医疗专业,博士学位;
2000-2001年,波士顿大学生化系,访问学者;
2001-2003年,麻省理工学院肿瘤研究中心,访问学者;
2003-2007年,加拿大多伦多大学,博士后;
2007年至今,澳门大阳城集团澳门大阳城集团2138网站,教授/博士生导师;
2011年至今,细胞应激生物学国家重点实验室副主任;
2017年获国家杰出青年科学基金资助。
M.S. 1999, Fourth Military Medical University, Clinical Medicine;
Ph.D. 2002, Fourth Military Medical University, Clinical Medicine;
Visiting Student, Boston University School of Medicine, 2000-2001;
Visiting Scholar, Massachusetts Institute of Technology, 2001-2003;
Postdoc Fellow, University of Toronto, 2003-2007;
Professor, School of Life Sciences, Xiamen University, 2007 to Present.

近年主要关注PI3K/AKT/FoxO通路与表观遗传修饰机制的互话在肿瘤耐药/肿瘤转移中的功能。另外,我们还关注应激刺激如何调控细胞分化,细胞凋亡,细胞自噬等生命活动。
The main interest of the lab is the understanding of the reciprocal regulation between PI3K/AKT/FoxO pathway and epigenetic modulation mechanisms. We are particularly interested in investigating how these crosstalks controlling chemoresistance and cancer metastasis. In addition, we are also interested in characterizing key molecules and signaling networks regulating cell differentiation, apoptosis and autophagy.

代表性论文(# co-first author, * Corresponding author):

1. Gong, Z., Li AC., Ding JC., Li, Q., Zhang L., Li YP., Meng Z., Chen F., Huang JL., Zhou DW., Hu RG., Ye, J., Liu W. and You, H*. OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis and Breast Cancer Metastasis. Adv Sci (Weinh) . 2021. Aug;8(15):e2004504.
2. 2 . Zhang, L., Cai, M., Gong, Z., Zhang, B., Li, Y., Guan, L., Hou, X., Li, Q., Liu, G., Xue, Z., Yang, M. H., Ye, J., Chin, Y. E. and You, H*. Geminin facilitates FoxO3 deacetylation to promote breast cancer cell metastasis. J Clin Invest. 2017, 127(6):2159-2175
3. Guan L, Zhang L, Gong Z, Hou X, Xu Y, Feng X, Wang H, You H*. FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance via Keap1-Nrf2 signaling. Hepatology 2016, 63(6):1914-1927
4. Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, Wu M, Wang Z, Han J, You H*. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 2015, 11(9):1623-1635.
5. Jiao H, Su GQ, Dong W, Zhang L, Xie W, Yao LM, Chen P, Wang ZX, Liou YC, You H*. Chaperone-like protein p32 regulates ULK1 stability and autophagy. Cell Death Differ.,2015, 22(11):1812-1823.
6. Zhang L, Mei Y, Fu NY, Guan L, Xie W, Liu HH, Yu CD, Yin Z, Yu VC, You H*.TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21. PNAS . , 2012, 109(51), pp 20937-20942.
7. Zhang YR, Xing Y, Zhang L, Mei Y, Yamamoto K, Mak TW*, You H*.Regulation of cell cycle progression by FOXO3 through a its binding partner Cdt1. PNAS. ,2012. 109(15), pp 5717-5722
8. Mei Y, Wang Z,Zhang L, Zhang YR, Li XY, Liu HH, Ye J, You H*. Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO 1/3/4 through the receptor tyrosine kinase PDGFRA. PNAS. ,2012. 109(13), pp 4898-4903
9. Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H*, Kwiatkowski D, Zhang H*. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. PNAS. ,2011, 108(10):4129-34.
10. Mei Y, Zhang YR, Yamamoto K, Xie W, Mak TW*, You H*. FoxO3a -dependent regulation of Pink1/Park6 mediates survival signaling in response to cytokine deprivation. PNAS., 2009, 106(13):5153-8.

荣誉、奖励及参加学术团体的情况: