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王海滨教授博导

邮  箱:haibin.wang@vip.163.com

职称/职务:教授 博士生导师

联系方式:0592-2880501

  • 个人简介
  • 科研领域
  • 代表性成果

1992~1996 中国农业大学生理学专业,理学学士 2000~2001 日本东京农工大农学部家畜生理学,短期交换留学生 1996~2001 中国农业大学生理学专业,理学博士 2001~2002 美国堪萨斯大学医学中心,博士后 2002~2008 历任美国范德堡大学医学中心博士后,研究助理教授,助理教授 2008~2016 中国科学院动物研究所,研究员 2016~至今 澳门大阳城集团,特聘教授

生殖过程是一个由母体与子体共同参与的被精确调控的生理过程,其中的早期胚胎发育、胚泡着床与随后的胎盘发生是决定妊娠能否成功的关键环节。研究组主要利用动物模型结合人类临床资源和多种新兴研究策略研究早期胚胎发育、着床与胎盘发生的生理和病理调节机制,具体包括:(1)囊胚激活的分子机制;(2)子宫接受态建立和蜕膜化的分子调控网络;(3)胎盘发育过程中滋养层细胞命运分化的决定。通过对以上关键过程的研究,深入揭示妊娠建立和维持的分子机理,为预防和治疗与上述生殖过程相关的女性生殖疾病提供参考和借鉴。

代表性论文(# co-first author, * Corresponding author):

1. Xin Q#, Kong S#, Yan J#, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Bmi-1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 128(1):175-189, 2018
2. Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. Dec;24(12):2013-2021, 2017
3. Ran H#, Kong S#, Zhang S#, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 114(18):4816-4821, 2017
4. Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 23(1):169-81, 2016
5. Zhang S#, Kong S#, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res., 24(8):925-42, 2014
6.Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 11(4):e1001536, 2013
7. Lim H* & Wang H*. Uterine disorders and pregnancy complications: insights from mouse models. J CIin Invest. 120(4), 1004-15, 2010
8. Xie H, Tranguch S, Jia X, Zhang H, Das SK, Dey SK, Kuo CJ, and Wang H. Inactivation of Nuclear Wnt-β-Catenin Signaling Limits Blastocyst Competency for Implantation. Development. 135: 717-727, 2008
9. Xie H#, Wang H#, Tranguch S, Iwamoto R, Mekada E, DeMayo FJ, Lydon JP, Das SK and Dey SK. Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.Proc Natl Acad Sci USA. 104(46): 18315-20, 2007
10. Wang H and Dey SK. Roadmap to embryo implantation: Clues from mouse models. Nature Review Genetics. 7 (3): 185-199, 2006
11. Wang H, Xie H, Guo Y, Zhang H, Takahashi T, Kingsley PJ, Marnett LJ, Das SK, Cravatt BF and Dey SK. Fatty acid amide hydrolase deficiency limits early pregnancy events. J CIin Invest. 116 (8): 2122-2131, 2006
12. Wang H#, Tranguch S#, Xie H, Hanley G, Das SK, Dey SK. Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. Proc Natl Acad Sci USA.102 (28): 9960-9965, 2005
13.Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK,DuBois RN and Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nature Medicine.10: 1074-1080, 2004
14. Wang H, Matsumoto H, Guo Y, Paria BC, Roberts RL, and Dey SK. Differential G-Protein coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation. Proc Natl Acad Sci USA. 100(25): 14914-14919, 2003

荣誉、奖励及参加学术团体的情况: