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王耿教授博导

邮  箱:wangengfuan@163.com

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

1998年,澳门大阳城集团化学专业,学士学位;
2006年,美国爱荷华大学生物化学与分子生物学,博士学位;
2006-2012年,加州大学洛杉矶分校化学与生物化学系,博士后;
2012-2019年,清华大学澳门大阳城集团2138网站,特别研究员/博士生导师;
2019年至今,澳门大阳城集团澳门大阳城集团2138网站,教授/博士生导师。
B.S. 1998, Xiamen University, Chemistry;
Ph.D. 2006, University of Iowa, Biochemistry and Molecular Biology;
Postdoctoral fellow, University of California, Los Angeles, 2006-2012;
Principle Investigator, Tsinghua University, 2012-2019;
Professor, School of Life Sciences, Xiamen University, 2019 to Present.

线粒体RNA的运输、代谢和功能,及其和其他重要细胞过程之间的关联和调控;线粒体疾病的医疗研究;哺乳动物正常衰老机制的研究。
Mitochondrial RNA import, metabolism, functions, and the regulation network between them and other important cellular processes; Therapeutic research on mitochondrial diseases; Mechanistic study of normal ageing in mammals.

代表性论文(# co-first author, * Corresponding author):

1. Zheng Q, Liu P, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Di F, Tong T, Chen J, Lu Z, Guan J,Wang G*. (2019) Mitochondrion-processed TERC regulates senescence without affecting telomerase activities. Protein Cell, doi: 10.1007/s13238-019-0612-5. [Epub ahead of print].
2. Huang J, Liu P,Wang G*. (2018) Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2). J biol chem, 293, 19633-19644.
3. Cheng Y, Liu P, Zheng Q, Gao G, Yuan J, Wang P, Huang J, Xie L, Lu X, Tong T, Chen J, Lu Z, Guan J,Wang G*. (2018) Mitochondrial Trafficking and Processing of Telomerase RNA TERC. Cell Reports, 24(10):2589-2595.
4. Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J,Wang G* (2017) Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2. Protein & Cell 8(1): 735-749.
5. Wang G, Shimada E, Nili M, Koehler CM, Teitell MA (2015) Mitochondria-targeted RNA import. Methods Mol Biol. 1264:107-116.
6. Wang G, Shimada E, Koehler CM, Teitell MA (2012) PNPASE and RNA trafficking into mitochondria. Biochimi Biophys Acta. 1819(9-10):998-1007.
7. Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM (2012) Correcting human mitochondrial mutations with targeted RNA import. Proc Natl Acad Sci U S A. 109(13):4840-4845.
8. von Ameln S,Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, Nürnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, Nürnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C (2012) A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. Am J Hum Genet. 91(5):919-927.
9. Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC 3rd, Koehler CM, Teitell MA (2010) PNPASE regulates RNA import into mitochondria. Cell. 142(3):456-467.
10. Wang G, Deschenes RJ (2006) Plasma membrane localization of Ras requires class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae. Mol Cell Biol, 26:3243-3255.

荣誉、奖励及参加学术团体的情况:

主持1项科技部国家重点研发计划、1项国家自然科学基金重大研究计划培育项目。