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欧阳高亮教授博导

邮  箱:oygldz@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2186091

  • 个人简介
  • 科研领域
  • 代表性成果

1993年,南昌大学生物学专业,学士学位;
1998年,澳门大阳城集团生物学专业,硕士学位;
2001年,澳门大阳城集团动物学专业,博士学位;
2004年至今,澳门大阳城集团澳门大阳城集团2138网站,副教授/教授。
B.S. 1993, Nanchang University, Biology;
M.S. 1998, Xiamen University, Biology;
Ph.D. 2001, Xiamen University, Zoology;
Associate Professor/Professor, School of Life Sciences, Xiamen University, 2010 to present.

肿瘤转移是一复杂的多步骤过程,涉及肿瘤细胞侵袭转移至靶器官、适应并重塑靶器官的组织微环境。本课题组主要致力于组织微环境与肿瘤转移研究,系统阐明了Periostin蛋白在炎症微环境和肿瘤组织微环境中的功能及其对肿瘤转移的调控作用。目前主要研究Periostin等基质蛋白在组织微环境重塑和肿瘤转移中的作用机制。
Tumor metastasis is a complex multi-step process, involving dissemination of cancer cells to distant organ sites and their subsequent adaptation to and remodeling of foreign tissue microenvironments. Our research group is mainly devoted to the study of tissue microenvironment and tumor metastasis, and have elucidated the function of periostin in inflammatory microenvironments and tumor microenvironments and its regulatory role in tumor metastasis. We will continue to investigate the mechanisms of periostin and other matricellular proteins in tissue microenvironment remodeling and tumor metastasis.

代表性论文(# co-first author, * Corresponding author):

1. Xiao H, Zhang Y, Li Z, Liu B, Cui D, Liu F, Chen D*, Liu Y*, Ouyang G*. Periostin deficiency reduces diethylnitrosamine-induced liver cancer in mice by decreasing hepatic stellate cell activation and cancer cell proliferation. J Pathol, 2021; 255(2): 212-223.
2. Ma H, Wang J, Zhao X, Wu T, Huang Z, Chen D, Liu Y*, Ouyang G*. Periostin promotes colorectal tumorigenesis through integrin-FAK-Src pathway-mediated YAP/TAZ activation. Cell Rep, 2020; 30(3): 793-806.e6.
3. Ma Z, Zhao X, Deng M, Huang Z, Wang J, Wu Y, Cui D, Liu Y, Liu R*, Ouyang G*. Bone marrow mesenchymal stromal cell-derived periostin promotes B-ALL progression by modulating CCL2 in leukemia cells. Cell Rep, 2019; 26(6): 1533-1543.e4.
4. Wu T, Huang J, Wu S, Huang Z, Chen X, Liu Y, Cui D, Song G, Luo Q, Liu F*, Ouyang G*. Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy. Matrix Biol, 2018; 66: 81-92.
5. Ma Z, Zhao X, Huang J, Jia X, Deng M, Cui D, Du Z, Fu G*, Ouyang G*, Xiao C*. A critical role of periostin in B-cell acute lymphoblastic leukemia. Leukemia, 2017; 31(8): 1835-1837.
6. Wang Z, Xiong S, Mao Y, Chen M, Ma X, Zhou X, Ma Z, Liu F, Huang Z, Luo Q, Ouyang G*. Periostin promotes immunosuppressive premetastatic niche formation to facilitate breast tumour metastasis. J Pathol, 2016; 239(4): 484-495.
7. Li Y, Wu S, Xiong S, Ouyang G*. Deficiency of periostin protects mice against methionine-choline-deficient diet-induced nonalcoholic steatohepatitis. J Hepatol, 2015; 62(2): 495-497.
8. Wu T, Luo Q*, Ouyang G*. Periostin: a potent chemotactic factor for recruiting tumor-associated macrophage. Protein Cell, 2015; 6(4): 235-237.
9. Wu T, Wu S, Ouyang G*. Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. Cell Metab, 2014; 20(4): 562-564. (Preview)
10. Liu AY, Zheng H, Ouyang G*. Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol, 2014; 37: 150-156.
11. Wu T, Ouyang G*. Matricellular proteins: multifaceted extracellular regulators in tumor dormancy. Protein Cell, 2014; 5: 249-252.
12. Liu AY, Ouyang G*. Tumor angiogenesis: glioblastoma stem cells as a new source of pericytes. Curr Biol, 2013; 23(13): R565-R568.
13. Wang Z, Ouyang G*. Periostin: a bridge between cancer stem cells and their metastatic niche. Cell Stem Cell, 2012; 10(2): 111-112. (Preview)
14. Fang X, Cai Y, Liu J, Wang Z, Wu Q, Zhang Z, Yang CJ, Yuan L, Ouyang G*. Twist2 contributes to breast cancer progression by promoting an epithelial-mesenchymal transition and cancer stem-like cell self-renewal. Oncogene, 2011; 30(47): 4707-4720.
15. Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, Shao R, Anderson RM, Rich JN, Wang XF*. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell, 2004; 5(4): 329-339.

荣誉、奖励及参加学术团体的情况:

目前担任中国生理学会基质生物学专业委员会副主任委员、中国抗癌协会肿瘤转移专业委员会委员,为中国细胞生物学学会第11届理事、教育部新世纪优秀人才、福建省杰出青年科学基金获得者、福建省科技创新领军人才、ELSEVIER(爱思唯尔)2020年中国高被引学者、ELSEVIER(爱思唯尔)2021年中国高被引学者。