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陈颖教授博导

邮  箱:yingchen@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:+86-592-2880328

  • 个人简介
  • 科研领域
  • 代表性成果

1996年,复旦大学生物化学专业,学士学位;
1999年,中国预防医学科学院寄生虫病研究所病原生物学专业,硕士学位;
2006年,美国拉什大学免疫与微生物专业,博士;
2007-2012年,美国德克萨斯大学西南医学中心,博士后;
2013年至今,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 1996, Fudan University, Biochemistry;
M.S. 1999, Chinese Academy of Preventive Medicine, Pathogenic Organisms;
Ph.D. 2006, Rush University, Immunology and Microbiology;
Postdoctoral Fellow, UTSW Medical Center, 2007-2012;
Professor, School of Life Sciences, Xiamen University, 2013 to Present.

研究髓鞘形成胶质细胞的发育以及疾病发生的分子机制。
研究表观遗传学和染色质重塑调控髓鞘细胞(少突胶质细胞和雪旺氏细胞)分化和疾病的发生。
研究信号通路包括G蛋白偶联受体信号对神经胶质细胞分化和再生的调控。
The central goal of our research is to understand the molecular mechanisms of myelinating glial cell development and disease in the mammalian nervous systems.
Research in our lab will focus on two areas: (1)Epigenetic and chromatin remodeling control of myelinating cell (oligodendrocyte and Schwann cell) differentiation and disease. (2)Signaling mechanisms including GPCR signaling in glial differentiation and regeneration.

代表性论文(# co-first author, * Corresponding author):

1. A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism. Ou Z, Ma Y, Sun Y, Zheng G, Wang S, Xing R, Chen X, Han Y, Wang J, Lu QR, Zhao TJ, Chen Y. Cell Rep. 2019 Mar 12;26(11):2984-2997.
2. Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination. Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y.J Neurosci. 2016 Oct 12;36(41):10560-10573.
3. Olig2 Targets Chromatin Remodelers To Enhancers To Initiate Oligodendrocyte Differentiation. Yu Y*, Y. Chen*, B. Kim*, H. Wang, C. Zhao, X. He, L. Liu, W. Liu, L. M. N. Wu, M. Mao, J. R. Chan, J. Wu and Q. R. Lu Cell. 2013 152 1-14 (* Equal contribution)
4. HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination. Ying Chen, Haibo Wang, Sung Ok Yoon, Xiaomei Xu, Michael Hottiger, Haesun Kim, Eric N. Olson, and Q. Richard Lu. Nature Neuroscience. 2011 Apr;14(4):437-41.
5. The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell intrinsic timer of myelination. Chen, Y. H. Wu, S. Wang, H. Koito, J. Li, J. Hoang, F. Ye, S. S. Escobar, A. Gow, H. A. Arnett, B. D. Trapp, N. J. Karandikar, J. Hsieh and Q. R. Lu. Nature Neuroscience. 2009 12 1398-1406
6. The basic helix-loop-helix transcription factor olig2 is critical for reactive astrocyte proliferation after cortical injury. Chen Y, Miles DK, Hoang T, Shi J, Hurlock E, Kernie SG, Lu QR. J Neurosci. 2008 Oct 22;28(43):10983-9.

荣誉、奖励及参加学术团体的情况: