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陈航姿教授博导

邮  箱:chenhz@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2003年,澳门大阳城集团生物科学专业,学士学位;
2009年,澳门大阳城集团细胞生物学专业,博士学位;
2005年,新加坡国立大学生物科学系,访问学生;
2009年至今,澳门大阳城集团澳门大阳城集团2138网站,助理教授/副教授/教授。
B.S. 2003, Xiamen University, Biological Sciences;
Ph.D. 2009, Xiamen University, Cell Biology;
Visiting Students, Department of Biological Sciences, National University of Singapore, 2005;
Assistant Professor/Associate Professor/Professor, School of Life Sciences, Xiamen University, 2009 to Present.

关注肿瘤细胞的代谢调控机制与细胞命运决定,重点探讨肿瘤细胞感应代谢应激到适应代谢应激的过程,分析核受体等关键节点蛋白在信号传递及微环境重塑过程中的作用。
The main interest of our lab is the understanding of metabolic regulation and cell fate determination of tumor cells, focusing on the process of sensing and adaptation of tumor cells to metabolic stress, and analyzing the role of nuclear receptor and other key node proteins in signal transduction and microenvironment remodeling.

代表性论文(# co-first author, * Corresponding author):

1. Zhang JY#, Zhou B#, Sun RY#, Ai YL#, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ*, Qiao Wu*. The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. Cell Research. 2021 Sep;31(9):980-997.
2. Hou PP, Chen HZ*. Extracellular vesicles in the tumor immune microenvironment. Cancer Letters. 2021, 28;516:48-56.
3. Yang PB#, Hou PP#, Liu FY#, Hong WB#, Chen HZ#, Sun XY, Li P, Zhang Y, Ju CY, Luo LJ, Wu SF, Wang ZJ, He JP, Li L, Zhao TJ, Deng X, Lin T*, Wu Q*. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression. Proc Natl Acad Sci U S A. 2020, 117(44):27412-27422.
4. Hou PP#, Luo LJ#, Chen HZ#, Chen QT#, Bian XL#, Wu SF, Zhou JX, Zhao WX, Liu JM, Wang XM, Zhang ZY, Yao LM, Chen QH, Zhou DW, Wu Q*. Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment. Molecular Cell. 2020,78(6):1192-1206.
5. Guan YF#, Huang QL#, Ai YL, Chen QT, Zhao WX, Wang XM, Wu Q, Chen HZ*. Nur77-activated lncRNA WFDC21P Attenuates Hepatocarcinogenesis via Modulating Glycolysis. Oncogene. 2020, 39 (11), 2408-2423.
6. Zhou B#, Zhang JY#, Liu XS#, Chen HZ#, Ai YL, Cheng K, Sun RY, Zhou D, Han J, Wu Q*. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Research. 2018, 28(12):1171-1185.
7. He JP#, Hou PP#, Chen QT#, Wang WJ, Sun XY, Yang PB, Li YP, Yao LM, Li X, Jiang XD, Chien KY, Zhang ZM, Wu QW, Cowin AJ, Wu Q, Chen HZ*. Flightless-I Blocks p62-Mediated Recognition of LC3 to Impede Selective Autophagy and Promote Breast Cancer Progression. Cancer Research. 2018, 78(17):4853-4864.
8. Li XX#, Wang ZJ#, Zheng Y#, Guan YF#, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, Chien KY, Wu Q*, Chen HZ*. Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Molecular Cell. 2018, 69(3):480-492.
9. Bian XL#, Chen HZ#, Yang PB#, Li YP#, Zhang FN, Zhang JY, Wang WJ, Zhao WX, Zhang S, Chen QT, Zheng Y, Sun XY, Wang XM, Chien KY, Wu Q*. Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation. Nature Communications. 2017.8:14420
10. Li L#, Liu Y#, Chen HZ#, Li FW#, Wu JF, Zhang HK, He JP, Xing YZ, Chen Y, Wang WJ, Tian XY, Li AZ, Zhang Q, Huang PQ, Han J, Lin T*, Wu Q*. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nature Chemical Biology. 2015, 11(5):339-46.

荣誉、奖励及参加学术团体的情况:

2017年度福建省自然科学奖一等奖(第3完成人),2018年;
2012年度福建省自然科学奖一等奖(第2完成人),2013年;
福建省青年拔尖创新人才,2014年。