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刘波教授博导

邮  箱:bliu23@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2004年,澳门大阳城集团生物科学专业,学士学位;
2008年,澳门大阳城集团细胞生物学专业,硕士学位;
2012年,美国佛罗里达大学分子遗传与微生物学专业,博士学位;
2013-2016年,美国约翰霍普金斯大学霍华德休斯医学研究所,博士后;
2016-2018年,美国德克萨斯大学西南医学中心霍华德休斯医学研究所,博士后;
2018年,澳门大阳城集团南强青年拔尖人才(A类);
2018年至今,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 2004, Xiamen University, Biological Sciences;
M.S. 2008, Xiamen University, Cell Biology;
Ph.D. 2012, University of Florida, Molecular Genetics and Microbiology;
Postdoc Fellow, Johns Hopkins University, HHMI, 2013-2016;
Postdoc Fellow, UT Southwestern Medical Center, HHMI, 2016-2018;
Professor, Xiamen University, 2018 to Present.

Hippo信号通路是动物发育过程中控制器官大小的核心通路。它在肿瘤发生、干细胞分化、组织器官再生及先天免疫等过程中发挥重要作用。本课题组将以果蝇遗传学为主要手段,深入研究Hippo信号通路在动物发育及先天免疫中的作用机制。同时,我们还将以果蝇遗传筛选为基础,结合细胞生物学及比较基因组学等方法,鉴定新的器官大小调控基因及先天免疫因子。
The highly conserved Hippo signaling pathway plays pivotal roles in organ size control, tumorigenesis, stem cell differentiation, tissue regeneration and innate immunity. Using the genetically tractable Drosophila (fruit fly) as a model organism, our research will focus on how Hippo signaling pathway is involved in animal development and innate immunity. Meanwhile, by coupling Drosophila genetic screens with cell biology and comparative genomics, we will identify conserved factors that engage in organ size control and innate immunity.

代表性论文(# co-first author, * Corresponding author):

1. Shen R#, Zheng K#, Zhou Y, Chi X, Pan H, Wu C, Yang Y, Zheng Y, Pan D*, Liu B*. A dRASSF-STRIPAK-Imd-JAK/STAT axis controls antiviral immune response in Drosophila. Cell Reports. 40, 111143, 2022.
2. Zheng Y#, Liu B#, Wang L, Lei H, Pulgar Prieto KD, Pan D*. Homeostatic control of Hpo/MST kinase activity through autophosphorylation-dependent recruitment of the STRIPAK PP2A phosphatase complex. .Cell Reports. 2017, 21(12):3612-3623. (# co-first author)
3. Liu B, Zheng Y, Yin F, Yu J, Silverman N, Pan D*. Toll receptor-mediated Hippo signaling controls innate immunity in Drosophila. .Cell. 2016, 164(3): 406-419.
4. Zheng Y#*, Wang W#, Liu B, Deng H, Uster E, Pan D*. Identification of Happyhour/MAP4K as alternative Hpo/Mst-like kinases in the Hippo kinase cascade. .Developmental Cell. 2015, 34(6):642-55.
5. Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L*. P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster. .Plos Pathogens. 2013, 9(2):e1003137.
6. Bo Liu, James Becnel, Yanping Zhang, Lei Zhou*. Induction of reaper Ortholog mx in Mosquito midgut cells following baculovirus infection. .Cell Death Differentiation. 2011, 18(8):1337-45.
7. Lin N, Li X, Cui K, Chepelev I, Tie F, Liu B, Li G, Harte P, Zhao K, Huang S, Zhou L*. A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogaster and vertebrates. .Mol Cell Biol. 2011, 31(13):2729-41.
8. Bo Liu, Jia-fa Wu, Yan-yan Zhan, Hang-zi Chen, Xiao-yan Zhang and Qiao Wu*. Regulation of the orphan receptor TR3 nuclear functions by c-Jun N terminal kinase phosphorylation. .Endocrinology. 2007, 148(1): 34-44.
9. Zhao BX, Chen HZ, Lei NZ, Li GD, Zhao WX, Zhan YY, Liu B, Lin SC, Wu Q. p53 mediates the negative regulation of MDM2 by orphan receptor TR3. .EMBO J. 2006, 25(24):5703-15.

荣誉、奖励及参加学术团体的情况:

1. 2018年,国家高层次青年人才。
2. 2016年,美国UT MD Anderson 癌症中心“未来癌症研究”研讨会特邀报告人。
3. 2012年,美国University of Florida国际中心优秀留学生奖。
4. 2011年,美国University of Florida研究激励基金。
5. 2011年,中国国家优秀自费留学生奖学金。