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程喆副教授

邮  箱:chengzhe@xmu.edu.cn

职称/职务:副教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2003年,西北大学生命科学专业,学士学位;
2009年,澳门大阳城集团动物学专业,博士学位;
2020年,澳门大阳城集团澳门大阳城集团2138网站,副教授。
B.S. 2003, Northwest University, Life Science;
Ph.D. 2009, Xiamen University, Zoology;
Associate Professor, School of Life Sciences, Xiamen University, 2020 to Present.

以人体重要寄生病原泡球蚴为研究模型,探究宿主-寄生虫间的互作关系,分析宿主因子介导的相关信号通路在寄生虫生长发育过程中的作用;泡球蚴成体干细胞自我更新、多能性维持和细胞特化的机制以及宿主因子对其影响。
We utilize E. multilocularis, one of the most important human helminthic pathogens, as the experimental model to investigate the roles of host factor-mediated signaling pathways in parasite’s growth and development. We are particularly interested in the contributions of host factors to the self-renewal, pluripotency maintenance and cell specification of E. multilocularis somatic stem cells.

代表性论文(# co-first author, * Corresponding author):

1. Cheng Z, Xu Z, Tian H, Liu F, Li X, Luo D, Wang Y. In vitro and in vivo efficacies of the EGFR/MEK/ERK signaling inhibitors in the treatment of alveolar echinococcosis. Antimicrob Agents Chemother. 2020, 64(8): e00341-20.
2. Cheng Z, Liu F, Tian H, Xu Z, Chai X, Luo D, Wang Y. Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase. PLoS Negl Trop Dis. 2019, 13(5): e0007425.
3. Cheng Z, Liu F, Dai M, Wu J, Li X, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells. Int J Parasitol. , 2017, 47(10-11): 625-632.
4. Cheng Z, Liu F, Li X, Dai M, Wu J, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. PLoS Negl Trop Dis. , 2017, 11(2): e0005418.
5. Cheng Z, Zhu S, Wang L, Liu F, Tian H, Pengsakul T, Wang Y, Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response. Int J Parasitol. , 2015, 45(8): 517-526.
6. Cheng Z, Liu F, Zhu S, Wang L, Wang Y, A rapid and convenient method for fluorescence analysis of in vitro cultivated metacestode vesicles from Echinococcus multilocularis. PLoS One, 2015, 10(2): e0118215.
7. Cheng Z, Tian H, Chu H, Wu J, Li Y, Wang Y, The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Toxicol Lett. , 2014, 225(3): 413-421.
8. Wang Y#, Cheng Z#, Lu X, Tang C, Echinococcus multilocularis: Proteomic analysis of the protoscoleces by two-dimensional electrophoresis and mass spectrometry. Exp Parasitol. , 2009, 123(2): 162-167.

荣誉、奖励及参加学术团体的情况: