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王彦海副教授

邮  箱:wangyh@xmu.edu.cn

职称/职务:副教授

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

1991年,澳门大阳城集团动物学专业,学士学位;
2001年,澳门大阳城集团动物学专业,博士学位;
2008-2009年,美国The Scripps Research Institute访问学者;
2004年至今,澳门大阳城集团澳门大阳城集团2138网站,副教授。
B.S. 1991, Xiamen University, Zoology;
Ph.D. 2001, Xiamen University, Zoology;
Associate Professor, School of Life Sciences, Xiamen University, 2004 to Present.

寄生虫发育的分子机制及寄生虫与宿主相互作用。
以泡球蚴作为实验模型,利用实验室建立的体外泡球蚴细胞及囊泡培养系统,研究寄生虫生发细胞(干细胞)自我更新和分化机理,分析寄生蠕虫的代谢过程,探讨寄生蠕虫发育机理及其代谢机制。
寄生虫与宿主在长期共进化过程中可利用宿主因子达到定居、生长、发育与繁殖的目的,通过分析宿主相关因子在寄生蠕虫生长发育过程中的作用及其机理,探讨宿主与寄生虫之间复杂的相互作用关系。

代表性论文(# co-first author, * Corresponding author):

1. Cheng Z, Xu Z, Tian H, Liu F, Luo D, Wang Y*. In vitro and in vivo efficacies of inhibitors of the EGFR/MEK/ERK signaling in the treatment of alveolar echinococcosis. Antimicrob Agents Chemother . 2020 64(8): e00341-20.
2. Cheng Z#, Liu F, Tian H, Xu Z, Chai X, Luo D, Wang Y*. Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase. PLoS Negl Trop Dis, 2019, 13(5): e0007425.
3. Zhe Cheng, Fan Liu, Mengya Dai1, Jianjian Wu, Xiu Li1, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang*. Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells. International Journal for Parasitology, 2017, 47(10-11): 625-632 .
4. Zhe Cheng, Fan Liu, Xiu Li1, Mengya Dai1, Jianjian Wu, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang*. EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. PLOS Neglected Tropical Diseases , 2017, 11(2): e0005418.
5. Zhe Cheng, Shan Zhu, Liang Wang, Fan Liu, Huimin Tian, Theerakamol Pengsakul, Yanhai Wang*. Identification and characterisation of Emp53, the homologue of human tumor suppressor p53 from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response. International Journal for Parasitology, 2015, 42(8): 517-26.
6. Cheng, Zhe; Liu, Fan; Zhu, Shan; Tian, Huimin; Wang, Liang; Wang, Yanhai*. A Rapid and Convenient Method for Fluorescence Analysis of In Vitro Cultivated Metacestode Vesicles from Echinococcus multilocularis. PLos One, 2015, 10(2), e0118215 .
7. Zhe Cheng, Huimin Tian, Hongran Chu, Jianjian Wu, Yingying Li, Yanhai Wang*. The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Toxicol Lett, 2014, 225(3):413-21.
8. Zhirong Zhang, Xiaozheng Xu, Jianhui Ma, Jianfeng Wu, Yanhai Wang, Rongbin Zhou and Jiahuai Han*. Gene deletion of gabarap enhances nlrp3 inflammasome-dependent inflammatory responses. J Immunol, 2013, 190(7):3517-24.
9. Sangun Lee, Yanhai Wang*, Sung Ouk Kim, Jiahuai Han*. AMPD3 is involved in anthrax LeTx-induced macrophage cell death. Protein & Cell, 2011, 2(7):
10. Min Zheng, Yan-Hai Wang, Xiao-Nan Wu, Su-Qin Wu, Bao-Ju Lu, Meng-Qiu Dong, Hongbing Zhang, Peiqing Sun, Sheng-Cai Lin, Kun-Liang Guan, and Jiahuai Han*. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy depletion-induced suppression of mTORC1. Nature Cell Biology, 2011, 13(3):263-272 .
11. Xiao-Nan Wu, Xue-Kun Wang, Su-Qin Wu, Jiawei Lu, Min Zheng, Yan-Hai Wang, Huamin Zhou, Hongbing Zhang, Jiahuai Han*. Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. Journal of Biological Chemistry. 2011; 286(36):31501-11.
12. Yanhai Wang, Zhe Cheng , Xiaofeng Lu, Chongti Tang*. Echinococcus multilocularis: Proteomic analysis of the protoscoleces by two-dimensional electrophoresis and mass spectrometry. Experimental Parasitology, 2009, 123: 162–167.
13. Li Q, Lin S, Wang X, Lian G, Lu Z, Guo H, Ruan K, Wang Y, Ye Z, Han J, Lin SC*. 2009. Axin determines cell fate by controlling the p53 activation threshold after DNA damage. Nature Cell Biology, 2009;11(9):1128-34 .
14. Ce´line Levron, Larisa G. Poddubnaya, Roman Kuchta, Mark Freeman, Yan-Hai Wang, and Tomas Scholz*. SEM and TEM study of the armed male terminal genitalia of the tapeworm Paraechinophallus japonicus (Cestoda: Bothriocephalidea). Journal of Parasitology, 2008, 94(4):803-810.
15. Ce´line Levron, Larisa G. Poddubnaya, Roman Kuchta, Mark Freeman, Yan-Hai Wang, and Tomas Scholz*. Ultrastructure of the tegument of the cestode Paraechinophallus japonicus(Bothriocephalidea: Echinophallidae), a parasite of the bathypelagic fish Psenopsis anomala. Invertebrate Biology. 2008; 127(2):153-161 .
16. Qinxi Li, Na Zhang, Duanwu Zhang, Yuqian Wang, Tianwei Lin, Yanhai Wang, Huamin Zhou, Zhiyun Ye, Faming Zhang, Sheng-Cai Lin, and Jiahuai Han*. Determinants that control the distinct subcellular localization of p38alpha-PRAK and p38beta-PRAK complexes. J Biol Chem. 2008, 283(16):11014-23 .
17. Zailian Lu, Wei Liu, Huizhe Huang, Ying He, Ying Han, Yanhai Wang, Qinxi Li, Ka Ruan, Zhiyun Ye, Boon Chuan Low, Anming Meng, and Sheng-Cai Lin*. Protein encoded by the AxinFu allele effectively downregulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J Biol Chem. 2008, 283(19):13132-9.
18. Yang Ziqiang, Cheng Wei, Hong Lixin, Chen Wanze, Wang Yanhai, Lin Shengcai, Han Jiahuai, Zhou Huamin, Gu Jun*. Adenine nucleotide (ADP/ATP) translocase 3 participates in the tumor necrosis factor induced apoptosis of MCF-7 Cells. Molecular biology of the Cell. 2007, 18(11):4681-4689.
19. Li Hongtao, Wang Yanhai*. A New Species of Macrobothriidae (Cestoda: Diphyllidea) From Thornback Ray Platyrhina sinensis in China. Journal of Parasitology; 2007, 93(4):897-900.
20. Li Hongtao, Wang Yanhai*. A new species of Onchobothriidae (Tetraphyllidea) from Chiloscyllium plagiosum (Elasmobranchii: Orectolobidae) in China. Journal of Parasitology; 2006, 92(5):1050-1052.

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