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李剑副教授

邮  箱:jianli_204@xmu.edu.cn

职称/职务:副教授

联系方式:+86-592-2182861

  • 个人简介
  • 科研领域
  • 代表性成果

2019-至今,澳门大阳城集团,副教授
2011-2019,澳门大阳城集团,助理教授
2009-2011,美国国立卫生研究院(NIH),联培博士生
2005-2011,澳门大阳城集团,生物化学与分子生物学,博士
2000-2004,南昌大学,生物科学,学士
2019-present, Associate professor, Xiamen University
2011-2019, Assistant professor, Xiamen University
2009-2011, Joint PhD student, National Institutes of Health, USA
2005-2011, Ph.D., Xiamen University, Biochemistry and Molecular Biology
2000-2004, B.S., Nanchang University, Biological Sciences

1. 疟原虫-宿主互作的致病性毒力分子机制
2. 疟原虫抗药的遗传机制
3. 疟原虫时期发育的分子机制
1. Molecular mechanism of virulence involved in Plasmodium-host interactions
2. Genetic basis of drug resistance in malaria parasite
3. Mechanisms that control the parasite development at different stages

代表性论文(# co-first author, * Corresponding author):

1. Xu R, Liu Y, Fan R, Liang R, Yue L, Liu S, Su X-z*, Li J*: Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method. Int J Parasitol 2019, 49(9): 705-14.
2. Nair SC#, Xu R#, Pattaradilokrat S, Wu J, Qi Y, Zilversmit M, Ganesan S, Nagarajan V, Eastman RT, Orandle MS, Tan JC, Myers TG, Liu S, Long CA, Li J*, Su X-z*: A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence. Nature Communications 2017, 8(1): 223.
3. Su XZ*, Li J. Artemisinin and malaria: Current understandings of drug activation, action, and resistance. Chin Sci Bull 2017, 62(18): 1928-1937.
4. Yu X#, Cai B#, Wang M, Tan P, Ding X, Wu J, Li J, Li Q, Liu P, Xing C, Wang HY, Su X-z*, Wang R-F*: Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity 2016, 45(5): 1093-1107.
5. Li J*, Cai B, Qi Y, Zhao W, Liu J, Xu R, Pang Q, Tao Z, Hong L, Liu S, Leerkes M, Quiñones M, Su X-z*: UTR introns, antisense RNA and differentially spliced transcripts between Plasmodium yoelii subspecies. Malar J 2016, 15: 30.
6. Qi Y, Zhu F, Eastman RT, Fu Y, Zilversmit M, Pattaradilokrat S, Hong L, Liu S, McCutchan TF, Pan W, Xu W, Li J*, Huang F*, Su X-z*: Regulation of Plasmodium yoelii Oocyst Development by Strain- and Stage-Specific Small-Subunit rRNA. mBio 2015, 6(2): e00117-15.
7. Zhao W, Liu J, Xu R, Zhang C, Pang Q, Chen X, Liu S, Hong L, Yuan J, Li X, Chen Y, Li J*, Su X-z*: The Gametocytes of Leucocytozoon sabrazesi Infect Chicken Thrombocytes, Not Other Blood Cells. PLoS One 2015, 10(7): e0133478.
8. Wu J, Tian L, Yu X, Pattaradilokrat S, Li J, Wang M, Yu W, Qi Y, Zeituni AE, Nair SC, Crampton SP, Orandle MS, Bolland SM, Qi CF, Long CA, Myers TG, Coligan JE, Wang R*, Su X-z*: Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality. PNAS 2014, 111(4): E511-E520.
9. Pattaradilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zilversmit M, Nair SC, Huaman MC, Quinones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su X-z*. Plasmodium genetic loci linked to host cytokine and chemokine responses. Genes Immun 2014, 15(3):145-152.
10. Li J, Yuan J, Chen CC, Inglese J, Su X-z*: Chemical genomics for studying parasite gene function and interaction. Trends in Parasitol 2013, 29(12): 603-611.
11. Li J#, Pattaradilokrat S#, Zhu F#, Jiang H, Liu S, Hong L, Fu Y, Koo L, Xu W, Pan W, Carlton JM, Kaneko O, Carter R, Wootton JC, Su X-z*: Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii. PNAS 2011, 108(31): E374-E382.
12. Jiang H, Li N, Gopalan V, Zilversmit MM, Varma S, Nagarajan V, Li J, Mu J, Zilversmit M, Hayton K, Henschen B, Yi M, Stephens R, McVean GA, Awadala P, Wellems TE, Su X-z*. High chromosome recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biology 2011, 12(4): R33.
13. Pattaradilokrat S, Li J, Su X-z*: Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites. J Vis Exp 2011, (47). pii: 2365.
14. Li J, Zhang Y, Liu S, Hong L, Sullivan M, McCutchan TF, Carlton JM, Su X-z*: Hundreds of microsatellites for genotyping Plasmodium yoelii parasites. Mol Biochem Parasit 2009, 166(2): 153-158.
15. Li J, Zhang Y, Sullivan M, Hong L, Huang L, Lu F, McCutchan TF, Su X-z*: Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol Biochem Parasit 2007, 155(2): 94-102.

荣誉、奖励及参加学术团体的情况: