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黄添枝教授博导

邮  箱:E-mail:huangtianzhi@xmu.edu.cn

职称/职务:教授 博士生导师

联系方式:

  • 个人简介
  • 科研领域
  • 代表性成果

2007年,福建师范大学生物工程专业,学士学位;
2010年,澳门大阳城集团生化与分子生物学专业,硕士学位;
2013年,浙江大学生化与分子生物学专业,博士学位;
2013-2018年,美国西北大学,博士后;
2018-2021年,美国西北大学,研究助理教授;
2021年至今,澳门大阳城集团澳门大阳城集团2138网站,教授。
B.S. 2007, Fujian Normal University, Bio-engineering;
M.S. 2010, Xiamen University, Biochemistry and Molecular Biology;
Ph.D. 2013, Zhejiang University, Biochemistry and Molecular Biology;
Postdoctoral Fellow, Northwestern University, 2013-2018;
Research Assistant Professor, Northwestern University, 2018-2021;
Professor, School of Life Sciences, Xiamen University, 2021 to Present.

肿瘤干细胞是存在于肿瘤内极少数具有自我更新功能、多向分化潜能、能够启动和重建肿瘤组织表型能力的一类肿瘤细胞。肿瘤干细胞参与肿瘤的侵袭和转移、血管生成、抵抗化疗和放疗以及逃避免疫监视等过程。我们利用脑胶质瘤干细胞及其移植瘤模型,研究调控肿瘤干细胞的核心信号转导与细胞自噬和铁死亡调节机制方面,重点关注关键信号蛋白的重要蛋白翻译后修饰,从而诠释肿瘤干细胞增殖、自我更新和肿瘤发生发展的分子机制,并为脑胶质瘤的临床治疗提供新的思路与治疗靶点。
Cancer stem cells, a small fraction of cells within tumors, are shown to exhibit unique abilities including self-renewal, differentiation potential, tumor re-establishing. Cancer stem cells can cause tumor invasion and metastases, angiogenesis, resistance to chemotherapy and radiotherapy, and evasion of immune surveillance. Our study uses glioma stem cells (GSCs) and mice models to study the core signaling pathways involving cell autophagy and ferroptosis, specifically the posttranslational modifications of key proteins. Once better understood, it would be interesting to see how these signaling regulators affect the proliferation, self-renewal, tumorigenesis, progression, and therapy responses of GSCs, and provide new ideas and therapeutic targets for clinical treatment of glioma.

代表性论文(# co-first author, * Corresponding author):

1. Huang T, Kim CK, Alvarez AA, Pangeni RP, Wan X, Song X, Shi T, Yang Y, Sastry N, Horbinski CM, Lu S, Stupp R, Kessler JA, Nishikawa R, Nakano I, Sulman EP, Lu X, James CD, Yin XM, Hu B, Cheng SY. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell, 2017, 32: 840–855.
2. Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, Horbinski CM, Zeng C, Tiek D, Goenka A, Liu F, Brennan CW, Kessler JA, Stupp R, Nakano I, Sulman EP, Nishikawa R, James CD, Zhang W, Xu W, Hu B, Cheng SY. PRMT6 Methylation of RCC1 Regulates Mitosis, Tumorigenicity, and Radiation Response of Glioblastoma Stem Cells. Molecular Cell, 2021, 81(6):1276-1291.
3. Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, J Raizer J, A Kessler J, Brenann CW, Sulman EP, Finocchiaro G, Tan M, Nishikawa R, Lu X, Nakano I, Hu B, Cheng SY. A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nature Communications. 2016, 7:12885.
4. Huang T, Wan X, Alvarez AA, James CD, Song X, Yang Y, Sastry N, Nakano I, Sulman EP, Hu B, Cheng SY. MIR93 (microRNA -93) Regulates Tumorigenicity and Therapy Response of Glioblastoma by Targeting Autophagy. Autophagy, 2019, 15(6):1100-1111.
5. Huang T, Song X, Xu D, Tiek D, Goenka A, Wu B, Sastry N, Hu B, Cheng SY. Stem cell programs in cancer initiation, progression, and therapy resistance. Theranostics, 2020, 10(19):8721-8743.

荣誉、奖励及参加学术团体的情况: